Coxsackievirus B Infection Is Highly Related with Missed Abortion in Korea
- Coxsackievirus B Infection Is Highly Related with Missed Abortion in Korea
- 박호선; 황정혜[황정혜]; 김정욱[김정욱]; 황지영; 이경민; 심혜민; 배영경; 백승삼[백승삼]
- ADENOVIRUS RECEPTOR CAR; HERPES-SIMPLEX-VIRUS; INTRAUTERINE INFECTION; VIRAL INVASION; PREGNANCY; ENCEPHALITIS; MIDTRIMESTER; MISCARRIAGE; EXPRESSION; HEPATITIS
- Issue Date
- YONSEI UNIV COLL MEDICINE
- YONSEI MEDICAL JOURNAL, v.55, no.6, pp.1562 - 1567
- Purpose: This study investigated the possible relationship between viral infection and first trimester pregnancy loss. Materials and Methods: A prospective study was performed on 51 gravidas with missed abortion, fetal anomaly, pre-term delivery, and full-tern delivery at Hanyang University Hospital. Enteroviruses were detected by semi-nested reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry in abortive tissues and placentas. Enterovirus serotypes were confimied by genome sequencing. Hernesviruses were detected by PCR. Results: Coxsackievirus B3 (CVB3) was detected in 8 of 14 missed abortion cases, 1 of 27 full-term cases, and none of the 9 pre-term cases. Coxsackievirus B1 (CVB1) was detected in an encephalocele case. Herpes simplex virus type 1 was found in 4 full-term cases, 3 pre-term cases, and none of the missed abortion cases. Conclusion: The prevalence of CVB3 was significantly higher in missed abortion cases compared to full-term or pre-term delivery cases. CVB infection may therefore be an important etiological agent of missed abortion.
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