Coxsackievirus B Infection Is Highly Related with Missed Abortion in Korea

Title
Coxsackievirus B Infection Is Highly Related with Missed Abortion in Korea
Author(s)
박호선황정혜[황정혜]김정욱[김정욱]황지영이경민심혜민배영경백승삼[백승삼]
Keywords
ADENOVIRUS RECEPTOR CAR; HERPES-SIMPLEX-VIRUS; INTRAUTERINE INFECTION; VIRAL INVASION; PREGNANCY; ENCEPHALITIS; MIDTRIMESTER; MISCARRIAGE; EXPRESSION; HEPATITIS
Issue Date
201411
Publisher
YONSEI UNIV COLL MEDICINE
Citation
YONSEI MEDICAL JOURNAL, v.55, no.6, pp.1562 - 1567
Abstract
Purpose: This study investigated the possible relationship between viral infection and first trimester pregnancy loss. Materials and Methods: A prospective study was performed on 51 gravidas with missed abortion, fetal anomaly, pre-term delivery, and full-tern delivery at Hanyang University Hospital. Enteroviruses were detected by semi-nested reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry in abortive tissues and placentas. Enterovirus serotypes were confimied by genome sequencing. Hernesviruses were detected by PCR. Results: Coxsackievirus B3 (CVB3) was detected in 8 of 14 missed abortion cases, 1 of 27 full-term cases, and none of the 9 pre-term cases. Coxsackievirus B1 (CVB1) was detected in an encephalocele case. Herpes simplex virus type 1 was found in 4 full-term cases, 3 pre-term cases, and none of the missed abortion cases. Conclusion: The prevalence of CVB3 was significantly higher in missed abortion cases compared to full-term or pre-term delivery cases. CVB infection may therefore be an important etiological agent of missed abortion.
URI
http://hdl.handle.net/YU.REPOSITORY/30505http://dx.doi.org/10.3349/ymj.2014.55.6.1562
ISSN
0513-5796
Appears in Collections:
의과대학 > 미생물학교실 > Articles
의과대학 > 영상의학과학교실 > Articles
의과대학 > 병리학교실 > Articles
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