A selective determination of levodopa in the presence of ascorbic acid and uric acid using a glassy carbon electrode modified with reduced graphene oxide

Title
A selective determination of levodopa in the presence of ascorbic acid and uric acid using a glassy carbon electrode modified with reduced graphene oxide
Author(s)
심재진트란트룽히유웬방호아
Keywords
SENSITIVE SIMULTANEOUS DETERMINATION; L-DOPA; ELECTROCHEMICAL SENSOR; PARKINSONS-DISEASE; GRAPHITE ELECTRODE; HUMAN SERUM; NANOTUBES; CARBIDOPA; METHYLDOPA; COMPOSITE
Issue Date
201411
Publisher
SPRINGER
Citation
JOURNAL OF APPLIED ELECTROCHEMISTRY, v.44, no.5, pp.589 - 597
Abstract
A selective determination of levodopa (LD) in the presence of ascorbic acid (AA) and uric acid (UA) has been investigated at a glassy carbon electrode modified with reduced graphene oxide (rGO). The graphene oxide was synthesized chemically by Hummers method and characterized by energy-filtered transmission electron microscopy (EF-TEM). The reduced graphene oxide modified glassy carbon electrode (rGO/GCE) showed excellent electrochemical performance in the simultaneous electrochemical detection of LD, AA, and UA due to the unique properties of graphene, such as large surface area, facile electronic transport and high electrocatalytic activity. The redox characteristics of rGO/GCE were investigated with cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Well-resolved oxidation peak potentials, corresponding to the oxidation of AA, LD, and UA, were observed from their mixture solution at 0.098, 0.285, and 0.423 V, respectively. The rGO/GCE showed that LD can be detected without the interference of AA and UA. Under the optimized conditions, the oxidation peak current of LD is linear with the concentration of LD from 2.0 to 100 mu M with the detection limit of 1.13 mu M (S/N = 3). The present electrode system was also successfully applied to direct determination of LD in commercially available tablets and urine samples.
URI
http://hdl.handle.net/YU.REPOSITORY/30456http://dx.doi.org/10.1007/s10800-013-0649-8
ISSN
0021-891X
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공과대학 > 화학공학부 > Articles
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