Prognostic significance of Bcl-2 expression in non-basal triple-negative breast cancer patients treated with anthracycline-based chemotherapy

Title
Prognostic significance of Bcl-2 expression in non-basal triple-negative breast cancer patients treated with anthracycline-based chemotherapy
Author(s)
배영경최정은강수환이수정
Keywords
PATHOLOGICAL COMPLETE RESPONSE; MYELOID-LEUKEMIA CELLS; NEOADJUVANT CHEMOTHERAPY; POOR RESPONSE; PROTEIN; MARKER; CARCINOMAS; ADJUVANT; DOXORUBICIN; LYMPHOMA
Issue Date
201412
Publisher
SPRINGER
Citation
TUMOR BIOLOGY, v.35, no.12, pp.12255 - 12263
Abstract
B cell lymphoma/leukemia-2 (Bcl-2) expression has generally been associated with estrogen receptor positivity and favorable prognosis in breast cancer. We examined immunohistochemical expression of Bcl-2 in 492 triple-negative breast cancers (TNBCs) using tissue microarrays and investigated its correlation with clinicopathologic features and clinical outcome. A total of 47 (9.5 %) TNBCs showed Bcl-2 expression. Bcl-2 expression was not associated with any of the clinicopathologic parameters and did not affect patient survival in TNBCs (Bcl-2-positive vs Bcl-2-negative TNBCs; overall survival (OS), P=0.258; disease-free survival (DFS), P=0.436). When TNBCs were divided into basal (cytokeratin 5/6 (CK5/6)+ and/or epidermal growth factor receptor (EGFR)+) and non-basal (CK5/6- and EGFR-) subgroups, Bcl-2 expression showed a significant association with worse OS (P=0.002) andDFS (P=0.002) in the non-basal subgroup. Among patients treated with an anthracycline, Bcl-2 expression also showed an association with decreased survival (OS, P=0.004; DFS, P=0.003) in the non-basal subgroup. In multivariate analyses, Bcl-2 expression was an independent poor prognostic factor for OS (P=0.003) and DFS (P=0.002) in this subgroup of TNBCs. Our results suggest that positive expression of Bcl-2 predicts no benefit from adjuvant anthracycline-based chemotherapy in non-basal TNBC patients. In conclusion, Bcl-2 status showed both prognostic and predictive values in non-basal TNBCs; therefore, assessment of Bcl-2 status and basal phenotype can provide information on prognostic and therapeutic classifications of TNBCs.
URI
http://hdl.handle.net/YU.REPOSITORY/30343http://dx.doi.org/10.1007/s13277-014-2534-4
ISSN
1010-4283
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의과대학 > 병리학교실 > Articles
의과대학 > 성형외과학교실 > Articles
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