Layer-by-layer assembly of liposomal nanoparticles with PEGylated polyelectrolytes enhances systemic delivery of multiple anticancer drugs

Title
Layer-by-layer assembly of liposomal nanoparticles with PEGylated polyelectrolytes enhances systemic delivery of multiple anticancer drugs
Author(s)
김종오티르거네쉬라마사미최주연트란탄힙하이다[하이다]정지헌용철순신범수[신범수]최한곤[최한곤]
Keywords
POLYMERIC MULTILAYER CAPSULES; SOLID LIPID NANOPARTICLES; CANCER-THERAPY; DOXORUBICIN; MICELLES; CHITOSAN; CORE; NANOCARRIERS; NANOCAPSULES; FORMULATION
Issue Date
201412
Publisher
ELSEVIER SCI LTD
Citation
ACTA BIOMATERIALIA, v.10, no.12, pp.5116 - 5127
Abstract
Layer-by-layer (LbL)-engineered nanoparticles (NPs) are a promising group of therapeutic carriers used in an increasing number of biomedical applications. The present study uses a controlled LbL process to create a multidrug-loaded nanoplatform capable of promoting blood circulation time, biodistribution profile and controlling drug release in the dynamic systemic environment. LbL assembly is achieved by sequential deposition of poly-c-lysine (PLL) and poly(ethylene glycol)block-poly(L-aspartic acid) (PEG-b-PLD) on liposomal nanoparticles (LbL-LNPs). This generates spherical and stable multilayered NP similar to 240 nm in size, enabling effective systemic administration. The numerous functional groups and compartments in the polyelectrolyte shell and core facilitate loading with doxorubicin and mitoxantrone. The nanoarchitecture effectively controls burst release, providing different release kinetics for each drug. LbL-LNPs are pH-sensitive, indicating that intracellular drug release can be increased by the acidic milieu of cancer cells. We further demonstrate that the LbL nanoarchitecture significantly reduces the elimination rates of both drugs tested and markedly extends their systemic circulation times, paving the way for efficacious tumor drug delivery. Because this delivery system accommodates multiple drugs, improves drug half-life and diminishes burst release, it provides an exciting platform with remarkable potential for combination therapeutics in cancer therapy. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd . All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/30335http://dx.doi.org/10.1016/j.actbio.2014.08.021
ISSN
1742-7061
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약학대학 > 약학부 > Articles
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