The effect of Epigallocatechin-3-Gallate in allergic airway inflammation

Title
The effect of Epigallocatechin-3-Gallate in allergic airway inflammation
Author(s)
김용대최윤석배창훈송시연
Keywords
INDUCED MUC5B EXPRESSION; INDUCED MUCIN PRODUCTION; EPITHELIAL-CELLS; GENE-EXPRESSION; MUCUS HYPERSECRETION; MATRIX-METALLOPROTEINASE-9; ASTHMA; DOXYCYCLINE; SECRETION; MMP-9
Issue Date
201412
Publisher
INT RHINOLOGIC SOC
Citation
RHINOLOGY, v.52, no.4, pp.406 - 412
Abstract
Background: The variety of beneficial effects of green tea has been reported. Epigallocatechin-3-gallate (EGCG) is a major component of green tea extract. The biological activity of EGCG includes anti-allergic and anti-inflammatory activities. However, the precise effect of EGCG on the allergic airway inflammation has not been fully defined. Methodology: In lung tissues of an asthma model-mouse, and nasal epithelial cells of patients with allergic rhinitis, the effect and brief signaling pathway of EGCG on MUC5B expression were investigated using real-time polymerase chain reaction, immunohistochemical, and immunoblot analysis. Results: In the asthma model-mouse, mucus production, MUC5B expression, p38 mitogen-activated protein kinase (MAPK) and matrix nnetalloprotease (MMP)-9 expression of the asthma group were significantly higher than in the control group. Extracellular signal related kinase (ERK)1/2 MAPK expression did not change. Mucus production, MUC5B expression, p38 MAPK expression, and MMP-9 expression of the asthma + EGCG group were significantly lower than in the asthma group. In the nasal epithelial cells of patients with allergic rhinitis, EGCG significantly decreased phorbol 12-myristate 13-acetate (PMA)-induced MUC5B and MMP-9 expression. Conclusion:These results suggest that EGCG reduces mucin expression in the asthma model-mouse and nasal epithelial cells of patients with allergic inflammation.
URI
http://hdl.handle.net/YU.REPOSITORY/30324http://dx.doi.org/10.4193/Rhino13.189
ISSN
0300-0729
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의과대학 > 이비인후과학교실 > Articles
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