Preparation and Characterization of Fenofibrate-Loaded Nanostructured Lipid Carriers for Oral Bioavailability Enhancement

Title
Preparation and Characterization of Fenofibrate-Loaded Nanostructured Lipid Carriers for Oral Bioavailability Enhancement
Author(s)
김종오트란탄힙티르거네쉬라마사미트롱두이히유최한곤[최한곤]용철순
Keywords
DRUG-DELIVERY SYSTEM; VIVO EVALUATION; NANOPARTICLES; OPTIMIZATION; NANOCRYSTALS; DISSOLUTION; DESIGN; SMEDDS; ACID; SLN
Issue Date
201412
Publisher
SPRINGER
Citation
AAPS PHARMSCITECH, v.15, no.6, pp.1509 - 1515
Abstract
The aim of this study is to investigate the potential of nanostructured lipid carriers (NLCs) in improving the oral bioavailability of a lipid lowering agent, fenofibrate (FEN). FEN-loaded NLCs (FEN-NLCs) were prepared by hot homogenization followed by an ultrasonication method using Compritol 888 ATO as a solid lipid, Labrafil M 1944CS as a liquid lipid, and soya lecithin and Tween 80 as emulsifiers. NLCs were characterized in terms of particle size and zeta pote\ntial, surface morphology, encapsulation efficiency, and physical state properties. Bioavailability studies were carried out in rats by oral administration of FEN-NLC. NLCs exhibited a spherical shape with a small particle size (84.9 +/- 4.9 nm). The drug entrapment efficiency was 99% with a loading capacity of 9.93 +/- 0.01% (w/w). Biphasic drug release manner with a burst release initially, followed by prolonged release was depicted for in vitro drug release studies. After oral administration of the FEN-NLC, drug concentration in plasma and AUCt-8 was fourfold higher, respectively, compared to the free FEN suspension. According to these results, FEN-NLC could be a potential delivery system for improvement of loading capacity and control of drug release, thus prolonging drug action time in the body and enhancing the bioavailability.
URI
http://hdl.handle.net/YU.REPOSITORY/30323http://dx.doi.org/10.1208/s12249-014-0175-y
ISSN
1530-9932
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약학대학 > 약학부 > Articles
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