Trogopterins A-C: Three new neolignans from feces of Trogopterus xanthipes

Title
Trogopterins A-C: Three new neolignans from feces of Trogopterus xanthipes
Author(s)
심상희백소윤XUIKUI XIA[XUIKUI XIA]박찬일[박찬일]민병선[민병선]
Keywords
ABSOLUTE-CONFIGURATION; CYTOTOXIC ACTIVITY; CHINESE-MEDICINE; DITERPENOIDS; TRITERPENES; GOREISHI
Issue Date
201412
Publisher
BEILSTEIN-INSTITUT
Citation
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, v.10, pp.2955 - 2962
Abstract
Seven compounds, including three neolignans 1-3, a norlignan 4, and three diterpenoids 5-7, were isolated from the feces of Trogopterus xanthipes. Structures of these compounds were identified by 1D and 2D NMR as well as MS. The absolute configurations of compounds 1, 2, and 4 were determined by comparing CD spectra and optical rotations. Among the isolated compounds, 1-3 were novel and subsequently named trogopterins A, B, and C, respectively. Likewise, compound 4 was isolated from nature for the first time. Cytotoxic activities of compounds 1-4 were evaluated. Compounds 1-3 exhibited moderate cytotoxic activities against HL-60 cells with IC50 values of 34.77-45.68 mu M.
URI
http://hdl.handle.net/YU.REPOSITORY/30319http://dx.doi.org/10.3762/bjoc.10.313
ISSN
1860-5397
Appears in Collections:
생명공학부 > 생명공학부 > Articles
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