The antiproliferative effects of compounds isolated from Schisandra chinensis

Title
The antiproliferative effects of compounds isolated from Schisandra chinensis
Author(s)
심상희서원세박소연민병선[민병선]김세현[김세현]송정호[송정호]
Keywords
Schisandra chinensis
Issue Date
201412
Citation
Korean Journal of Food Science and Technology, v.46, no.6, pp.665 - 670
Abstract
We isolated twelve lignans and three terpenoids were isolated from the n-hexane fraction of Schisandra chinensis extract. Using spectroscopic data and comparison with available literature, the following compounds were identified: (1) wuweizisu C, (2) gomisin N, (3) deoxyschisandrin, (4) gomisin A, (5) schisandrin, (6) chamigrenal, (7) schisanlactone D, (8) methylgomisin O, (9) angeloylgomisin O, (10) (-)-gomisin L2, (11) schisandronic acid, (12) (-)-gomisin L1, (13) (+)-gomisin K3, (14) gomisin J, and (15) tigloylgomisin H. Notably, this was the first finding that compound (8) was isolated from this plant. Each compound was evaluated for its in vitro cytotoxic activities toward HL-60 (human leukemia), HeLa (human cervical carcinoma), and MCF-7 (breast cancer) cell lines. Compounds (7), (8), and (9) exhibited strong cytotoxic effects on HL-60 (IC50 7.37, 6.60, and 8.00 ��M, respectively), whereas compound (6) exhibited weak cytotoxicity towards MCF-7 (IC50 30.50 ��M). In addition, compound (8) showed the strongest activity towards HeLa cells (IC50 1.46 ��M). ?The Korean Society of Food Science and Technology
URI
http://hdl.handle.net/YU.REPOSITORY/30279http://dx.doi.org/10.9721/KJFST.2014.46.6.665
ISSN
0367-6293
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생명공학부 > 생명공학부 > Articles
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