Risk Factors for Mortality in Stable Peritoneal Dialysis Patients

Title
Risk Factors for Mortality in Stable Peritoneal Dialysis Patients
Author(s)
도준영강석휘[강석휘]조규향박종원윤경우
Keywords
RESIDUAL RENAL-FUNCTION; C-REACTIVE PROTEIN; NONDIABETIC PATIENTS; ELDERLY-PATIENTS; HEMODIALYSIS-PATIENTS; PREDICTS MORTALITY; SURVIVAL; COMORBIDITY; ADEQUACY; CLEARANCE
Issue Date
201201
Publisher
INFORMA HEALTHCARE
Citation
RENAL FAILURE, v.34, no.2, pp.149 - 154
Abstract
Background: The mortality rates of end-stage renal disease patients have significantly declined over the past decade. However, there are few reports on the risk factors for mortality in stable peritoneal dialysis (PD) patients who survive for a considerable time. Patients and methods: We reviewed the medical records and identified all adult patients who received PD between April 2001 and March 2009 in our institution. The total cohort was 550 patients. Among these patients, 383 patients were enrolled as stable PD patients. Results: The cumulative survival of the stable PD patients was 91.6% at 3 years and 78.7% at 5 years. On univariate analysis, old age (>= 65 years of age), hypoalbuminemia (<35 g/L), log C-reactive protein (CRP) (>= 0.84), phosphorus (<1.13 mmol/L), statin, icodextrin, and the Davies index were associated with mortality for all PD patients. Old age, hypoalbuminemia, log CRP, phosphorus, the residual renal function (RRF) (<= 4 mL/min/1.73 m(2)) at 24 months, renin-angiotensin system blockade, icodextrin, and the Davies index were associated with mortality for the stable PD patients. Multivariate analysis showed that, among the variables, age, log CRP, phosphorus, initial RRF, and the Davies index were associated with mortality for all PD patients. In stable PD patients, age, log CRP, phosphorus, RRF at 24 months, and the Davies index were associated with mortality. Conclusion: Initial high RRF combined with the RRF preservation, maintenance of proper phosphorus, control of inflammation, and proper management of comorbidities may help to improve the survival of PD patients including stable PD patients.
URI
http://hdl.handle.net/YU.REPOSITORY/30098http://dx.doi.org/10.3109/0886022X.2011.646808
ISSN
0886-022X
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의과대학 > 내과학교실 > Articles
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