ZIRCONIA-BASED STATIONARY PHASES FOR CHIRAL SEPARATION: MINI REVIEW

Title
ZIRCONIA-BASED STATIONARY PHASES FOR CHIRAL SEPARATION: MINI REVIEW
Author(s)
박정학프라빈쿠마르
Keywords
PERFORMANCE LIQUID-CHROMATOGRAPHY; 2,4-DINITROPHENYL AMINO-ACIDS; CARBON-CLAD ZIRCONIA; CELLULOSE TRIS(3,5-DIMETHYLPHENYLCARBAMATE)-COATED ZIRCONIA; ION-EXCHANGE MATERIALS; CAPILLARY ELECTROCHROMATOGRAPHY; COATED ZIRCONIA; ENANTIOMER SEPARATION; ENANTIOSEPARATION TECHNIQUES; CHEMICAL-CHARACTERIZATION
Issue Date
201201
Publisher
TAYLOR & FRANCIS INC
Citation
ANALYTICAL LETTERS, v.45, no.1, pp.15 - 42
Abstract
Separation of enantiomers is one of the most interesting and challenging tasks in the field of separation science. High-performance liquid chromatography (HPLC) and recently capillary electrochromatography (CEC) using chiral stationary phases (CSP) are two of the most useful techniques for both enantioseparation and determination of enantiomeric composition. Although silica has been extensively used as the base material for the stationary phases due to attractive properties including desirable mechanical strength, surface characteristics, catalytic inertness, and surface derivatization possibilities, it has some inherent shortcomings including the narrow range of pH and thermal stability. The zirconia-based stationary phases have shown excellent performance in the separation of wide range of compounds and have been considered as an alternative to silica-based stationary phases due to desirable chemical and physical properties such as resistance to thermal conditions, resistance to extreme pHs, and mechanical stability. Recently, zirconia-based CSPs in either particle-packed or monolithic columns have received considerable attention. This mini-review reports the development and applications of zirconia based stationary phases for chiral separations by HPLC and CEC.
URI
http://hdl.handle.net/YU.REPOSITORY/30091http://dx.doi.org/10.1080/00032719.2011.582553
ISSN
0003-2719
Appears in Collections:
이과대학 > 화학생화학부 > Articles
문과대학 > 중국언어문화학과 > Articles
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