Comparable Analysis of Outcomes for Allogeneic Peripheral Blood Stem Cell Transplantation from Matched Related and Matched Unrelated Donors in Acute Myeloid Leukemia

Title
Comparable Analysis of Outcomes for Allogeneic Peripheral Blood Stem Cell Transplantation from Matched Related and Matched Unrelated Donors in Acute Myeloid Leukemia
Author(s)
현명수이수정[이수정]채의수[채의수]김종광[김종광]정주섭[정주섭]조군제[조군제]조덕현[조덕현]김여경[김여경]류헌모[류헌모]엄현석[엄현석]이상민[이상민]주연돈[주연돈]원정호[원정호]박무림[박무림]김민경손상균[손상균]
Keywords
1ST COMPLETE REMISSION; FREE SURVIVAL; CHRONIC GRAFT; RISK; GVHD; HLA; MARROW; IMPACT; ADULTS
Issue Date
201201
Publisher
KARGER
Citation
ACTA HAEMATOLOGICA, v.127, no.2, pp.81 - 89
Abstract
This study compared the results of allogeneic peripheral blood stem cell transplantation (PBSCT) from unrelated and related donors in 142 consecutive patients with acute myeloid leukemia (AML). The cumulative incidence of acute graft-versus-host disease (GVHD) was 37.6% in the related PBSCT group and 53.7% in the unrelated PBSCT group. The cumulative incidence of extensive chronic GVHD was also higher in the unrelated PBSCT group (19.5%) than in the related PBSCT group (8.9%). The overall survival rate at 4 years was 62.4 +/- 5.4 and 53.8 +/- 1.2% (p = 0.535) in the related and unrelated PBSCT group, respectively. In a multivariate analysis, unrelated PBSCT was identified as a risk factor for the development of extensive chronic GVHD (hazard ratio = 3.019, p = 0.027). Unfavorable cytogenetics and the disease status at the time of transplantation were found to be related to overall survival. In the case of high-risk AML, the survival rate and relapse incidence were significantly better in the matched unrelated PBSCT group (p = 0.047 and 0.039, respectively). In conclusion, the allogeneic PBSCT outcomes for AML were comparable in the matched related and matched unrelated groups. Nonetheless, for high-risk AML patients, matched unrelated PBSCT was found to be preferable to matched related PBSCT. Copyright (C) 2011 S. Karger AG, Basel
URI
http://hdl.handle.net/YU.REPOSITORY/30030http://dx.doi.org/10.1159/000333133
ISSN
0001-5792
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의과대학 > 내과학교실 > Articles
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