Development of novel flurbiprofen-loaded solid self-microemulsifying drug delivery system using gelatin as solid carrier

Title
Development of novel flurbiprofen-loaded solid self-microemulsifying drug delivery system using gelatin as solid carrier
Author(s)
용철순김동욱[김동욱]강준혁[강준혁]오동훈[오동훈]최한곤[최한곤]
Keywords
SPRAY-DRYING TECHNIQUE; CYCLODEXTRIN INCLUSION COMPLEX; ENHANCED ORAL BIOAVAILABILITY; PHYSICOCHEMICAL CHARACTERIZATION; BEAGLE DOGS; DOSAGE FORM; FORMULATION; DISPERSION; PHARMACOKINETICS; OPTIMIZATION
Issue Date
201201
Publisher
INFORMA HEALTHCARE
Citation
JOURNAL OF MICROENCAPSULATION, v.29, no.4, pp.323 - 330
Abstract
To develop a novel flurbiprofen-loaded solid self-microemulsifying drug delivery system (solid SMEDDS) with improved oral bioavailability using gelatin as a solid carrier, the solid SMEDDS formulation was prepared by spray-drying the solutions containing liquid SMEDDS and gelatin. The liquid SMEDDS, composed of Labrafil M 1944 CS/Labrasol/Transcutol HP (12.5/80/7.5%) with 2% w/v flurbiprofen, gave a z-average diameter of about 100 nm. The flurbiprofen-loaded solid SMEDDS formulation gave a larger emulsion droplet size compared to liquid SMEDDS. Unlike conventional solid SMEDDS, it produced a kind of microcapsule in which liquid SMEDDS was not absorbed onto the surfaces of carrier but formed together with carrier in it. However, the drug was in an amorphous state in it like conventional solid SMEDDS. It greatly improved the oral bioavailability of flurbiprofen in rats. Thus, gelatin could be used as a carrier in the development of solid SMEDDS with improved oral bioavailability of poorly water-soluble drug.
URI
http://hdl.handle.net/YU.REPOSITORY/30015http://dx.doi.org/10.3109/02652048.2011.651497
ISSN
0265-2048
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약학대학 > 약학부 > Articles
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