Injury of the corticoreticular pathway in patients with proximal weakness following cerebral infarct: Diffusion tensor tractography study

Title
Injury of the corticoreticular pathway in patients with proximal weakness following cerebral infarct: Diffusion tensor tractography study
Author(s)
장성호도경희여상석이준
Keywords
CORTICOSPINAL TRACT; PREMOTOR CORTEX; STROKE PATIENTS; MAGNETIC STIMULATION; MOTOR RECOVERY; HUMAN BRAIN; LESIONS; RELIABILITY; PATTERNS; SYSTEM
Issue Date
201306
Publisher
ELSEVIER IRELAND LTD
Citation
NEUROSCIENCE LETTERS, v.546, pp.21 - 25
Abstract
The corticoreticular pathway (CRP) innervates mainly the proximal muscles of extremities. Identification of the CRP by diffusion tensor tractography (DTT) in the human brain has recently become possible. However, little is known about the relation between proximal weakness and injury of the CRP in stroke patients. In this study, we attempted to investigate the usefulness of DTT for elucidation of the relation between proximal motor weakness and injury of the CRP in patients with cerebral infarct. Among 247 consecutive patients with cerebral infarct, four hemiparetic patients who showed more severe weakness in proximal joints (shoulder and hip) than distal joints (finger and ankle) of the affected extremities were recruited for this study. Evaluation of motor function, DTT, and transcranial magnetic stimulation (TMS) for evaluation of the corticospinal tract state by analysis of the characteristics of the motor-evoked potential were performed at the early stage of cerebral infarct (mean: 17.0 days; range: 11-29). The integrity of the CST on DTT findings in the affected hemisphere was preserved in all four patients and TMS findings in terms of latency and amplitude showed within normal range (one patient) and partial injuries (three patients) of the corticospinal tract. By contrast, on DTT of the CRP in the affected hemispheres, we observed Wallerian degeneration in two patients and discontinuations at infarct level in two patients. The injury of the CRP appeared to attribute the proximal weakness of the shoulder and hip observed in these four patients. Therefore, DTT of the CRP would be useful for elucidating the relation between proximal weakness and injury of the CRP in patients with cerebral infarct. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/30000http://dx.doi.org/10.1016/j.neulet.2013.04.040
ISSN
0304-3940
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의과대학 > 재활의학교실 > Articles
의과대학 > 신경과학교실 > Articles
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