Hoiamide D, a marine cyanobacteria-derived inhibitor of p53/MDM2 interaction

Title
Hoiamide D, a marine cyanobacteria-derived inhibitor of p53/MDM2 interaction
Author(s)
최혁재Karla L. Malloy[Karla L. Malloy]Catherine Fiorilla[Catherine Fiorilla]Fred A. Valeriote[Fred A. Valeriote]Teatulohi Matainaho [Teatulohi Matainaho ]William H. Gerwick[William H. Gerwick]
Keywords
P53-MDM2 INTERACTION; P53-HDM2 INTERACTION; MDM2; P53; CANCER
Issue Date
201201
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.22, no.1, pp.683 - 688
Abstract
Bioassay-guided fractionation of two cyanobacterial extracts from Papua New Guinea has yielded hoiamide D in both its carboxylic acid and conjugate base forms. Hoiamide D is a polyketide synthase (PKS)/non-ribosomal peptide synthetase (NRPS)-derived natural product that features two consecutive thiazolines and a thiazole, as well as a modified isoleucine residue. Hoiamide D displayed inhibitory activity against p53/MDM2 interaction (EC(50) = 4.5 mu M), an attractive target for anticancer drug development. (C) 2011 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/29997http://dx.doi.org/10.1016/j.bmcl.2011.10.054
ISSN
0960-894X
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약학대학 > 약학부 > Articles
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