A comprehensive manually curated protein-protein interaction database for the Death Domain superfamily

Title
A comprehensive manually curated protein-protein interaction database for the Death Domain superfamily
Author(s)
박현호권동섭[권동섭]윤종환[윤종환]신수용[신수용]장태호[장태호]김홍기[김홍기]서인석[서인석]전주홍[전주홍]
Keywords
HUMAN-DISEASE; PYRIN DOMAIN; CELL-DEATH; APOPTOSIS; INFLAMMATION; RECRUITMENT; ACTIVATION; MEMBER; MOTIF; CARD
Issue Date
201201
Publisher
OXFORD UNIV PRESS
Citation
NUCLEIC ACIDS RESEARCH, v.40, no.D1, pp.D331 - D336
Abstract
The Death Domain (DD) superfamily, which is one of the largest classes of protein interaction modules, plays a pivotal role in apoptosis, inflammation, necrosis and immune cell signaling pathways. Because aberrant or inappropriate DD superfamily-mediated signaling events are associated with various human diseases, such as cancers, neurodegenerative diseases and immunological disorders, the studies in these fields are of great biological and clinical importance. To facilitate the understanding of the molecular mechanisms by which the DD superfamily is associated with biological and disease processes, we have developed the DD database (http://www.deathdomain.org), a manually curated database that aims to offer comprehensive information on protein-protein interactions (PPIs) of the DD superfamily. The DD database was created by manually curating 295 peer-reviewed studies that were published in the literature; the current version documents 175 PPI pairs among the 99 DD superfamily proteins. The DD database provides a detailed summary of the DD superfamily proteins and their PPI data. Users can find in-depth information that is specified in the literature on relevant analytical methods, experimental resources and domain structures. Our database provides a definitive and valuable tool that assists researchers in understanding the signaling network that is mediated by the DD superfamily.
URI
http://hdl.handle.net/YU.REPOSITORY/29992http://dx.doi.org/10.1093/nar/gkr1149
ISSN
0305-1048
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이과대학 > 화학생화학부 > Articles
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