Prognostic effect of age on survival of patients with stage I adenocarcinoma of the lung

Title
Prognostic effect of age on survival of patients with stage I adenocarcinoma of the lung
Author(s)
이관호류정선[류정선]최창민[최창민]양석철[양석철]송상윤[송상윤]전영준[전영준]장태원[장태원]김도진[김도진]장승훈[장승훈]양세훈[양세훈]이민기[이민기]조향정[조향정]장세진[장세진]김영태[김영태]조재화[조재화]최유덕[최유덕]남해성[남해성]김현정[김현정]서영주[서영주]
Keywords
NEVER-SMOKERS; CANCER; COMORBIDITY; SURGERY; SMOKING
Issue Date
201201
Publisher
PENSIERO SCIENTIFICO EDITOR
Citation
TUMORI, v.98, no.1, pp.99 - 104
Abstract
Aims and background. It is still unclear whether age is an independent prognostic factor in patients with stage I NSCLC. Methods. Five hundred and sixty-nine patients with stage I adenocarinoma who underwent surgical resection as first treatment were included. The effect on overall survival of age, gender, smoking habits, Charlson comorbidity index score (CCIS), type of surgery, tumor size and lymphatic or blood vessel invasion was analyzed. Results. When the patients were divided into four groups according to quartiles of age, distributions of gender, smoking habit, CCIS, histology, blood vessel invasion and adjuvant chemotherapy were significantly different among the four groups. Age, gender, smoking habit, CCIS, tumor size and lymphatic and blood vessel invasion were significantly associated with overall survival of the patients in Kaplan-Meier analysis (logrank, P <0.001, P <0.001, P = 0.029, P <0.001, P = 0.001, P = 0.001 and P = 0.007, respectively). Moreover, the highest quartile of age (over 68 years old) was a prominent determinant for a worse prognosis after adjustment for the confounding variables using a Cox proportional hazard model (adjusted hazard ratio = 2.735, 95% confidence interval = 1.623-4.608, P<0.001). Conclusions. The findings suggest that age is an important determinant of overall survival in patients with stage I adenocarcinoma. Therefore, age should be considered in classifying the patients into groups of higher or lower risk for death as well as in designing clinical trials.
URI
http://hdl.handle.net/YU.REPOSITORY/29987
ISSN
0300-8916
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의과대학 > 내과학교실 > Articles
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