2,4-Diaryl-5,6-dihydro-1,10-phenanthroline and 2,4-diaryl-5,6-dihydrothieno[2,3-h] quinoline derivatives for topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study

Title
2,4-Diaryl-5,6-dihydro-1,10-phenanthroline and 2,4-diaryl-5,6-dihydrothieno[2,3-h] quinoline derivatives for topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study
Author(s)
프리텀다빠라다깔끼유한영[유한영]박필훈이은영[이은영]전경화[전경화]나영화[나영화]조원제[조원제]권영주[권영주]이응석
Keywords
CAMPTOTHECIN; PYRIDINES; TERPYRIDINES; DNA
Issue Date
201202
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
BIOORGANIC CHEMISTRY, v.40, pp.67 - 78
Abstract
Designed and synthesized thirty-two 2,4-diaryl-5,6-dihydro-1,10-phenanthroline and 2,4-diaryl-5,6dihydrothieno[2,3-h] quinoline derivatives as rigid analogs of 2,4,6-trisubstituted pyridines were evaluated for topoisomerase I and II inhibitory activities as well as cytotoxicities against several human cancer cell lines. Structure-activity relationship study showed that [2,2'; 6',2 '']-terpyridine skeleton is important for the cytotoxicity against several human cancer cell lines. (C) 2011 Elsevier Inc. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/29931http://dx.doi.org/10.1016/j.bioorg.2011.09.001
ISSN
0045-2068
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약학대학 > 약학부 > Articles
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