Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: The selenium paradox (Review)

Title
Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: The selenium paradox (Review)
Author(s)
정대원이경희
Keywords
MITOCHONDRIAL PERMEABILITY TRANSITION; KASHIN-BECK OSTEOARTHROPATHY; PROSTATE-CANCER CELLS; WHITE MUSCLE DISEASE; KESHAN-DISEASE; THIOREDOXIN REDUCTASE; OXIDATIVE STRESS; SODIUM SELENITE; VITAMIN-E; INDUCED APOPTOSIS
Issue Date
201202
Publisher
SPANDIDOS PUBL LTD
Citation
MOLECULAR MEDICINE REPORTS, v.5, no.2, pp.299 - 304
Abstract
Selenium is an essential biological trace element. Adult daily intake of selenium should be approximately 100 jig per day. This compound has a two-sided effect depending on its concentration. A selenium-deficient diet is associated with various endemic diseases, including cardiomuscular malfunctions, osteoarthritis, cancer and viral infections that lead to premature death. These defects are prevented when dietary intake of selenium is adequate. The preventive biological effect of selenium is considered to be due to the antioxidant function of selenoproteins with a selenocysteine in the active site of the catalytic domain. Antioxidant selenoproteins maintain the intracellular redox status and, as a result, normal physiological processes in the cell. Conversely, an overdose of selenium generates oxygen radicals and leads to apoptotic cell death by inducing oxidation and cross-linking of protein thiol groups essential for cell survival. A lower redox state caused by selenium may be implicated in toxic diseases, such as alkali disease and blind staggers. Collectively, selenium seems to have both harmful and beneficial attributes. The aim of this review is to summarize the various biological functions of selenium and to illustrate its opposite roles as a pro-oxidant and an antioxidant.
URI
http://hdl.handle.net/YU.REPOSITORY/29910http://dx.doi.org/10.3892/mmr.2011.651
ISSN
1791-2997
Appears in Collections:
의과대학 > 미생물학교실 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE