Expression of Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor 1 Receptor is Associated with the Favorable Clinicopathologic Parameters in Small Intestinal Carcinomas

Title
Expression of Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor 1 Receptor is Associated with the Favorable Clinicopathologic Parameters in Small Intestinal Carcinomas
Author(s)
구미진신형찬배영경정은선[정은선]오영하[오영하]
Keywords
FACTOR-I RECEPTOR; GASTROINTESTINAL-STROMAL-TUMORS; THERAPEUTIC TARGET; COLORECTAL-CANCER; CELL CARCINOMA; IGF-II; OVEREXPRESSION; ADENOCARCINOMA; PHENOTYPE; GISTS
Issue Date
201306
Publisher
KARGER
Citation
PATHOBIOLOGY, v.80, no.5, pp.265 - 270
Abstract
Objective: The insulin-like growth factor (IGF) system has been known to play a critical role in tumor development and progression in many human cancers. However, the role of the IGF system in small intestinal carcinoma (SIC) has not been studied yet. Methods: We evaluated the expression of IGF1 and IGF1 receptor (IFG1R) in a total of 194 cases of SIC. Results: IGF1 expression was associated with well/moderate differentiation, better survival, lower pT, lower stage and no lymph node metastasis. IGF1R was more diffusely and strongly expressed in tumors with lower pT and lower stage. Conclusions: IGF1 and IGF1R expression is associated with favorable clinicopathologic parameters and may involve early carcinogenesis of SICs. Target therapy for the IGF1R signaling pathway may not have a major therapeutic role in treating SIC. Copyright (C) 2013 S. Karger AG, Basel
URI
http://hdl.handle.net/YU.REPOSITORY/29902http://dx.doi.org/10.1159/000350309
ISSN
1015-2008
Appears in Collections:
의과대학 > 병리학교실 > Articles
의과대학 > 영상의학과학교실 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE