Natural Vanadium-Containing Jeju Groundwater Inhibits Immunoglobulin E-Mediated Anaphylactic Reaction and Suppresses Eicosanoid Generation and Degranulation in Bone Marrow Derived-Mast Cells

Title
Natural Vanadium-Containing Jeju Groundwater Inhibits Immunoglobulin E-Mediated Anaphylactic Reaction and Suppresses Eicosanoid Generation and Degranulation in Bone Marrow Derived-Mast Cells
Author(s)
장현욱이선[이선]유예[유예]양주혜[양주혜]김엽[김엽]황승락
Keywords
SODIUM ORTHOVANADATE; HISTAMINE-SECRETION; CROSS-LINKING; 5-LIPOXYGENASE; RECEPTOR; VANADATE; IGE; LEUKOTRIENES; ACTIVATION; EXPRESSION
Issue Date
201202
Publisher
PHARMACEUTICAL SOC JAPAN
Citation
BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.35, no.2, pp.216 - 222
Abstract
The high-affinity receptor for immunoglobulin E (IgE) (Fc epsilon RI)-mediated activation of mast cells plays an important role in various allergic diseases. To assess the anti-allergic activity of natural vanadium-containing Jeju groundwater (JW), an in vivo passive cutaneous anaphylaxis (PCA) animal model and in vitro mouse bone marrow-derived mast cells (BMMCs) was used. JW inhibited cyclooxygenase-2 (COX-2)-dependent prostaglandin D-2 (PGD(2)) generation in a dose-dependent manner, with a concomitant reduction of COX-2 protein expression in IgE-induced BMMCs. In addition, JW inhibited 5-lipoxygenase (5-LOX)-dependent generation of leukotriene C-4 (LTC4) as well as degranulation in a dose-dependent manner. These results demonstrate that JW has dual COX-2/5-LOX inhibitory activity. In addition, vanadium pentoxide (V2O5), which is the major vanadium component of JW, also inhibited PGD(2) and LTC4 generation as well as degranulation in IgE-induced BMMCs. Furthermore, oral administration of JW dose-dependently inhibited mast cell-dependent passive anaphylactic reaction in IgE-sensitized mice. Taken together, these results suggest that JW may be useful in regulating mast cell-mediated allergic response through the suppression of eicosanoid generation and degranulation in mast cells.
URI
http://hdl.handle.net/YU.REPOSITORY/29886
ISSN
0918-6158
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약학대학 > 약학부 > Articles
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