Effect of oral administration of water-soluble extract from citrus peel (Citrus unshiu) on suppressing alcohol-induced fatty liver in rats

Title
Effect of oral administration of water-soluble extract from citrus peel (Citrus unshiu) on suppressing alcohol-induced fatty liver in rats
Author(s)
성언기Sang Kyu Noh[Sang Kyu Noh]Ho-Young Park[Ho-Young Park]Yongkon Park[Yongkon Park]Youngsuk Lee[Youngsuk Lee]Inwook Choi[Inwook Choi]
Keywords
LIQUID-CHROMATOGRAPHY; LIPID-METABOLISM; FLAVONOIDS; HESPERETIN; DISEASE; ANTIOXIDANTS; INFLAMMATION; CONSUMPTION; INHIBITION; MECHANISM
Issue Date
201202
Publisher
ELSEVIER SCI LTD
Citation
FOOD CHEMISTRY, v.130, no.3, pp.598 - 604
Abstract
Water-soluble citrus peel extract (WCE) from Citrus unshiu was studied for its anti-alcoholic fatty liver activities through chronic oral administration to Sprague Dawley (SD) rats. WCE, which was prepared by ultrasound-assisted extraction (UAE), was co-supplemented with ethanol (2.87 ml/rat/day) at low and high dosages (278 and 576 mg/rat/day, respectively) for E. weeks. Ethanol consumption significantly elevated both total cholesterol (TC) and triglyceride (TG) concentrations in the serum of SD rats: otherwise co-administration of WCE lowered both serum TG and IC levels. Ethanol consumption caused a hepatic lipid content of 227 mg/g liver after 6 weeks whereas co-administration of WCE, especially at high dosage, significantly reduced it to 187 mg/g of liver. Analysis of hepatic fatty acids revealed that WCE suppressed conjugation of oleic acid into TG. These results support probable application of WCE as an anti-alcoholic fatty liver agent. (C) 2011 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/29870http://dx.doi.org/10.1016/j.foodchem.2011.07.081
ISSN
0308-8146
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의과대학 > 해부학교실 > Articles
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