Effects of Berberine on Hippocampal Neuronal Damage and Matrix Metalloproteinase-9 Activity Following Transient Global Cerebral Ischemia

Title
Effects of Berberine on Hippocampal Neuronal Damage and Matrix Metalloproteinase-9 Activity Following Transient Global Cerebral Ischemia
Author(s)
류호상홍정석[홍정석]추연경이 형[이 형]안병훈[안병훈]박재형[박재형]김미정[김미정]이승혜[이승혜]장정희[장정희]이승룡[이승룡]박종욱[박종욱]
Keywords
BLOOD-BRAIN-BARRIER; GENE KNOCK-OUT; MATRIX METALLOPROTEINASES; GERBIL HIPPOCAMPUS; FOREBRAIN ISCHEMIA; CELL-DEATH; IN-VITRO; INJURY; INFLAMMATION; PROTEOLYSIS
Issue Date
201202
Publisher
WILEY-BLACKWELL
Citation
JOURNAL OF NEUROSCIENCE RESEARCH, v.90, no.2, pp.489 - 497
Abstract
Berberine, an isoquinoline alkaloid with a long history of use in Chinese medicine, has several important pharmacological effects. Several studies have revealed that berberine has neuroprotective and neuropsychiatric effects. However, there are few reports regarding the protective effect of berberine against neuronal damage following transient global cerebral ischemia. In this study, mice were subjected to 20 min of global brain ischemia and sacrificed 72 hr later. Berberine was administered for 7 days prior to ischemia and daily until sacrifice. Mice treated with berberine showed reduced matrix metalloproteinase-9 (MMP-9) activity. Berberine inhibited gelatinase activity directly in in situ zymography and reduced neuronal damage following global ischemia. Laminin expression and NeuN expression were markedly reduced in CA1 and CA2 areas after ischemia, and berberine reduced the laminin degradation and neuronal loss. In the TUNEL assay, damaged neurons were also apparent in the CA1 and CA2 areas, and berberine reduced TUNEL-positive cells. These data demonstrate that berberine, a plant alkaloid, may protect from hippocampal neuronal damage following transient global ischemia by reducing MMP-9 activity. (C) 2011 Wiley Periodicals, Inc.
URI
http://hdl.handle.net/YU.REPOSITORY/29860http://dx.doi.org/10.1002/jnr.22756
ISSN
0360-4012
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생활과학대학 > 체육학부 > Articles
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