Alpha (1,2)-Fucosyltransferase M307A Polymorphism Improves Piglet Survival

Title
Alpha (1,2)-Fucosyltransferase M307A Polymorphism Improves Piglet Survival
Author(s)
김종주김경태[김경태]딘통누엔[딘통누엔]최민경[최민경]김진회[김진회]서한국[서한국]하이루데디[하이루데디]차세연[차세연]서근호[서근호]이윤미박찬규[박찬규]
Keywords
ENTEROTOXIGENIC ESCHERICHIA-COLI; BLOOD-GROUP ANTIGENS; CLOSTRIDIUM-PERFRINGENS TYPE; SOW BREEDING UNITS; EDEMA DISEASE; FUT1 GENE; NECROTIZING ENTERITIS; PREWEANING MORTALITY; POSTWEANING DIARRHEA; EPITHELIAL-CELLS
Issue Date
201306
Publisher
TAYLOR & FRANCIS INC
Citation
ANIMAL BIOTECHNOLOGY, v.24, no.3, pp.243 - 250
Abstract
To confirm the beneficial effects of alpha (1,2)-fucosyltransferase (FUT1) M307(A) on piglet survival on commercial farms, we performed PCR-RFLP analysis of FUT1 M307 in successfully marketed (n=245) and disease affected/deceased pigs during weaning (n=252) at a commercial farm. We also evaluated the FUT1 genotypes of 190 healthy pigs from three different genetic backgrounds. The distribution of genotypes differed between the successfully marketed and disease affected/deceased pig groups. The frequency of the A allele, associated with resistance to edema and post-weaning diarrhea, was higher in the post-weaning survival group (0.21) than in the non-survival group (0.16, P<0.05). The odds ratio for piglet survival between AA and GG genotypes was 1.98; thus, piglet survival for individuals with the AA genotype was almost two-fold greater than for GG individuals. The FUT1 gene polymorphism can be used as an effective marker for selection programs to improve post-weaning piglet survival.
URI
http://hdl.handle.net/YU.REPOSITORY/29858http://dx.doi.org/10.1080/10495398.2013.776964
ISSN
1049-5398
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생명공학부 > 생명공학부 > Articles
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