Probing the antiamoebic and cytotoxicity potency of novel tetrazole and triazine derivatives

Title
Probing the antiamoebic and cytotoxicity potency of novel tetrazole and triazine derivatives
Author(s)
최인호Mohmmad Younus Wani[Mohmmad Younus Wani]Amir Azam[Amir Azam]Fareeda Athar[Fareeda Athar]압둘루프바트
Keywords
CARBONIC-ANHYDRASE-II; ANTICONVULSANT AGENTS; ENTAMOEBA-HISTOLYTICA; BIOLOGICAL EVALUATION; METRONIDAZOLE; INHIBITORS; DISCOVERY; ANTAGONISTS; RESISTANCE; TOXICITY
Issue Date
201202
Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Citation
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.48, pp.313 - 320
Abstract
A series of compounds bearing a Tetrazole and Triazine ring motif conjugated with a SO2NH function were synthesized and investigated for their antiamoebic potency. Cytotoxicity of the compounds was checked on human hepatocellular carcinoma cell line HepG2. Incorporation of Triazine ring in place of tetrazole resulted in a precipitous increase in the antiamoebic activity of the compounds. Antiamoebic activity of the investigated compounds was found to be position and substituent dependent. In vitro cytotoxicity results revealed noncytotoxic nature of all the tested compounds up to a concentration of 25 mu M. Compound 5c and 5d were obtained as least cytotoxic (IC50 > 100 mu M) and excellent Entamoeba histolytica inhibitors with IC50 values of 1.05 mu M and 1.02 mu M respectively. (C) 2011 Elsevier Masson SAS. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/29831http://dx.doi.org/10.1016/j.ejmech.2011.12.033
ISSN
0223-5234
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생명공학부 > 생명공학부 > Articles
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