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dc.contributor.author김용운ko
dc.contributor.author배기철ko
dc.contributor.author박재형[박재형]ko
dc.contributor.author나안예[나안예]ko
dc.contributor.author김선주[김선주]ko
dc.contributor.author안신병[안신병]ko
dc.contributor.author김상표[김상표]ko
dc.contributor.author오병철[오병철]ko
dc.contributor.author조호찬[조호찬]ko
dc.contributor.author송대규[송대규]ko
dc.date.accessioned2015-12-17T03:20:18Z-
dc.date.available2015-12-17T03:20:18Z-
dc.date.created2015-11-13-
dc.date.issued201306-
dc.identifier.citationDiabetes and Metabolism Journal, v.37, no.3, pp.196 - 206-
dc.identifier.issn2233-6079-
dc.identifier.urihttp://hdl.handle.net/YU.REPOSITORY/29787-
dc.identifier.urihttp://dx.doi.org/10.4093/dmj.2013.37.3.196-
dc.description.abstractBackground: The increasing prevalence of type 2 diabetes mellitus (T2DM) is associated with the rapid spread of obesity. Obesity induces insulin resistance, resulting in ��-cell dysfunction and thus T2DM. Green tea extract (GTE) has been known to prevent obesity and T2DM, but this effect is still being debated. Our previous results suggested that circulating green tea gallated catechins (GCs) hinders postprandial blood glucose lowering, regardless of reducing glucose and cholesterol absorption when GCs are present in the intestinal lumen. This study aimed to compare the effect of GTE with that of GTE coadministered with poly-��-glutamic acid (��-PGA), which is likely to inhibit the intestinal absorption of GCs. Methods: The db/db mice and age-matched nondiabetic mice were provided with normal chow diet containing GTE (1%), ��-PGA (0.1%), or GTE+��-PGA (1%:0.1%) for 4 weeks. Results: In nondiabetic mice, none of the drugs showed any effects after 4 weeks. In db/db mice, however, weight gain and body fat gain were significantly reduced in the GTE+��-PGA group compared to nondrug-treated db/db control mice without the corresponding changes in food intake and appetite. Glucose intolerance was also ameliorated in the GTE+��-PGA group. Histopathological analyses showed that GTE+��-PGA-treated db/db mice had a significantly reduced incidence of fatty liver and decreased pancreatic islet size. Neither GTE nor ��-PGA treatment showed any significant results. Conclusion: These results suggest that GTE+��-PGA treatment than GTE or ��-PGA alone may be a useful tool for preventing both obesity and obesity-induced T2DM. ? 2013 Korean Diabetes Association.-
dc.language영어-
dc.subjectepicatechin gallate-
dc.subjectepigallocatechin gallate-
dc.subjectgreen tea extract-
dc.subjectpolyglutamic acid-
dc.subjectanimal cell-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectanimal tissue-
dc.subjectappetite-
dc.subjectarticle-
dc.subjectbody fat-
dc.subjectcontrolled study-
dc.subjectdiet supplementation-
dc.subjectfatty liver-
dc.subjectfood intake-
dc.subjectglucose intolerance-
dc.subjecthistopathology-
dc.subjectintestine absorption-
dc.subjectmonotherapy-
dc.subjectmouse-
dc.subjectnon insulin dependent diabetes mellitus-
dc.subjectnonhuman-
dc.subjectobesity-
dc.subjectoral glucose tolerance test-
dc.subjectorgan size-
dc.subjectpancreas islet-
dc.subjecttherapy effect-
dc.subjecttreatment duration-
dc.subjectweight gain-
dc.titleEffect of green tea extract/poly-γ-glutamic acid complex in obese type 2 diabetic mice-
dc.typeArticle-
dc.identifier.scopusid2-s2.0-84879491024-
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의과대학 > 생리학교실 > Articles
의과대학 > 영상의학과학교실 > Articles
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