Effect of green tea extract/poly-γ-glutamic acid complex in obese type 2 diabetic mice

Effect of green tea extract/poly-γ-glutamic acid complex in obese type 2 diabetic mice
epicatechin gallate; epigallocatechin gallate; green tea extract; polyglutamic acid; animal cell; animal experiment; animal model; animal tissue; appetite; article; body fat; controlled study; diet supplementation; fatty liver; food intake; glucose intolerance; histopathology; intestine absorption; monotherapy; mouse; non insulin dependent diabetes mellitus; nonhuman; obesity; oral glucose tolerance test; organ size; pancreas islet; therapy effect; treatment duration; weight gain
Issue Date
Diabetes and Metabolism Journal, v.37, no.3, pp.196 - 206
Background: The increasing prevalence of type 2 diabetes mellitus (T2DM) is associated with the rapid spread of obesity. Obesity induces insulin resistance, resulting in ��-cell dysfunction and thus T2DM. Green tea extract (GTE) has been known to prevent obesity and T2DM, but this effect is still being debated. Our previous results suggested that circulating green tea gallated catechins (GCs) hinders postprandial blood glucose lowering, regardless of reducing glucose and cholesterol absorption when GCs are present in the intestinal lumen. This study aimed to compare the effect of GTE with that of GTE coadministered with poly-��-glutamic acid (��-PGA), which is likely to inhibit the intestinal absorption of GCs. Methods: The db/db mice and age-matched nondiabetic mice were provided with normal chow diet containing GTE (1%), ��-PGA (0.1%), or GTE+��-PGA (1%:0.1%) for 4 weeks. Results: In nondiabetic mice, none of the drugs showed any effects after 4 weeks. In db/db mice, however, weight gain and body fat gain were significantly reduced in the GTE+��-PGA group compared to nondrug-treated db/db control mice without the corresponding changes in food intake and appetite. Glucose intolerance was also ameliorated in the GTE+��-PGA group. Histopathological analyses showed that GTE+��-PGA-treated db/db mice had a significantly reduced incidence of fatty liver and decreased pancreatic islet size. Neither GTE nor ��-PGA treatment showed any significant results. Conclusion: These results suggest that GTE+��-PGA treatment than GTE or ��-PGA alone may be a useful tool for preventing both obesity and obesity-induced T2DM. ? 2013 Korean Diabetes Association.
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