Bioassay-guided l Isolation of Fatty Acid Synthase Inhibitory Diterpenoids from the Roots of Salvia miltiorrhiza Bunge

Title
Bioassay-guided l Isolation of Fatty Acid Synthase Inhibitory Diterpenoids from the Roots of Salvia miltiorrhiza Bunge
Author(s)
나민균장태수[장태수]장해연김금진김동우[김동우]민병선[민병선]강원구손건호[손건호]이승호
Keywords
BREAST-CANCER CELLS; TANSHINONE IIA; APOPTOSIS; CHEMISTRY; GROWTH; INDUCTION; DANSHEN
Issue Date
201203
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.35, no.3, pp.481 - 486
Abstract
Fatty acid synthase (FAS) is considered as a novel drug target for the development of anticancer and anti-obesity agents. Bioassay-guided fractionation of a n-hexane-soluble extract prepared from the roots of Salvia miltiorrhiza Bunge (Labiatae), using an in vitro enzyme assay, led to the isolation of five abietane diterpenoids: 15,16-dihydrotanshinone I (1), cryptotanshinone (2), tanshinone I (3), tanshinone IIA (4), and dansenspiroketallactone (5). Compounds 1-5 were tested for their in vitro FAS inhibitory activity and, except for compound 5 (IC50 > 100 mu M), compounds 1-4 inhibited the enzyme activity with IC50 values ranging from 12.0 to 30.3 mu M. Our findings may be partially related to the anticancer activity of abietane diterpenoids from the plant, suggesting a further study on the anticancer potential of tanshinone derivatives.
URI
http://hdl.handle.net/YU.REPOSITORY/29697http://dx.doi.org/10.1007/s12272-012-0311-8
ISSN
0253-6269
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약학대학 > 약학부 > Articles
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