Effects of Melandrium firmum methanolic extract on testosterone-induced benign prostatic hyperplasia in Wistar rats

Title
Effects of Melandrium firmum methanolic extract on testosterone-induced benign prostatic hyperplasia in Wistar rats
Author(s)
손종근이미영[이미영]신인식[신인식]서창섭[서창섭]이남훈[이남훈]하혜경[하혜경]신현규[신현규]
Keywords
5-ALPHA-REDUCTASE INHIBITORS; OXIDATIVE STRESS; VENTRAL PROSTATE; LIPID EXTRACT; FINASTERIDE; ANTIOXIDANT; MEN; APOPTOSIS; ANDROGEN; CELLS
Issue Date
201203
Publisher
ACTA PHARMACOLOGICA SINICA
Citation
ASIAN JOURNAL OF ANDROLOGY, v.14, no.2, pp.320 - 324
Abstract
Benign prostatic hyperplasia (BPH) is an age-related disease of unknown aetiology characterized by prostatic enlargement coincident with distinct alterations in tissue histomorphology. Instead of therapeutic agents that can cause severe side effects, plant extracts are frequently used to treat BPH. In this study, we investigated whether the Melandrium firmum methanolic extract (MFME) improves BPH, using the testosterone propionate (TP)-induced BPH rat model. Castration was performed via the scrotal route under sodium pentobarbital anaesthesia. BPH in castrated rats was generated via daily subcutaneous injections of TP (3 mg kg(-1)) dissolved in corn oil, for 4 weeks. MFME was administered daily by oral gavage at a dose of 200 mg kg(-1) for 4 weeks, along with the TP injections. The control group received injections of corn oil subcutaneously. At the scheduled termination of the experiment, all rats were killed and their prostates weighed; the relative prostate weight (prostate/body weight ratio) was calculated, and histomorphological changes in the prostate were examined. Additionally, we measured the levels of testosterone and dihydrotestosterone (DHT) in the serum and the prostate. Experimentally induced BPH led to marked decreases in the relative prostate weight and the DHT levels in the serum and the prostate. Histologically, BPH was evident in the ventral lobe of the prostate, and MFME treatment suppressed the severity of the lesions. These results indicate that MFME effectively inhibits the development of BPH induced by testosterone in a rat model. Further studies will be needed to identify the compound(s) responsibility for inducing the protective effect against BPH and determine its mechanism of action. Asian Journal of Andrology (2012) 14, 320-324; doi:10.1038/aja.2011.166; published online 9 January 2012
URI
http://hdl.handle.net/YU.REPOSITORY/29695http://dx.doi.org/10.1038/aja.2011.166
ISSN
1008-682X
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약학대학 > 약학부 > Articles
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