Deracemization of unnatural amino acid: homoalanine using D-amino acid oxidase and omega-transaminase

Title
Deracemization of unnatural amino acid: homoalanine using D-amino acid oxidase and omega-transaminase
Author(s)
윤형돈서영만[서영만]샘 매튜[샘 매튜]배한섭[배한섭]강용호이상협[이상협]김병기[김병기]
Keywords
KINETIC RESOLUTION; VITREOSCILLA HEMOGLOBIN; ASYMMETRIC-SYNTHESIS; FUSION PROTEIN; DERIVATIVES; DERACEMISATION; HYDROLYSIS; ESTERS
Issue Date
201203
Publisher
ROYAL SOC CHEMISTRY
Citation
ORGANIC & BIOMOLECULAR CHEMISTRY, v.10, no.12, pp.2482 - 2485
Abstract
A deracemization method was developed to generate optically pure L-homoalanine from racemic homoalanine using D-amino acid oxidase and omega-transaminase. A whole cell reaction using a biphasic system converted 500 mM racemic homoalanine to 485 mM L-homoalanine (>99% ee).
URI
http://hdl.handle.net/YU.REPOSITORY/29691http://dx.doi.org/10.1039/c2ob07161d
ISSN
1477-0520
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생명공학부 > 생명공학부 > Articles
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