Diffusion tensor imaging demonstrated radiologic differences between diplegic and quadriplegic cerebral palsy

Title
Diffusion tensor imaging demonstrated radiologic differences between diplegic and quadriplegic cerebral palsy
Author(s)
손수민장성호이은실김세윤여상석장민철이동규[이동규]
Keywords
WHITE-MATTER; CORTICOSPINAL TRACT; PRETERM INFANTS; MOTOR FUNCTION; FOCAL LESIONS; AXONAL INJURY; CHILDREN; BRAIN; ABNORMALITIES; ULTRASOUND
Issue Date
201203
Publisher
ELSEVIER IRELAND LTD
Citation
NEUROSCIENCE LETTERS, v.512, no.1, pp.53 - 58
Abstract
Little information is available on the use of imaging for the classification of cerebral palsy patients. The present study examined the radiological differences between quadriplegic cerebral palsy patients (QCP), diplegic cerebral palsy patients (DCP) and normal control subjects (NC) by performing diffusion tensor imaging (DTI) of the corticospinal tract (CST) of upper and lower extremities. Twenty-three cerebral palsy patients (11 QCP, 12 DCP) and 12 NC were enrolled. DTI were scanned using a 1.5T and the CST images were analyzed using FMRIB software. We measured the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values of the CST. Compared to DCP and NC, QCP had decreased mean FA and increased mean ADC values of the CSTs of upper and lower extremities. The mean FA values of the lower extremities in DCP were significantly decreased, compared to NC; however this was not observed for the mean FA value of the upper extremities. The DTI results of the CST in QCP and DCP significantly corresponded with their typical clinical manifestation. DTI may thus be a very powerful modality to assess the state of CST in cerebral palsy patients. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/29673http://dx.doi.org/10.1016/j.neulet.2012.01.065
ISSN
0304-3940
Appears in Collections:
의과대학 > 재활의학교실 > Articles
의과대학 > 소아청소년과학교실 > Articles
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