Safety and feasibility of countering neurological impairment by intravenous administration of autologous cord blood in cerebral palsy

Title
Safety and feasibility of countering neurological impairment by intravenous administration of autologous cord blood in cerebral palsy
Author(s)
손수민이영호[이영호]최경빈[최경빈]문진화[문진화]전현주[전현주]강혜령[강혜령]오세인[오세인]김현선[김현선]엄장수[엄장수]김미정[김미정]
Keywords
BEHAVIORAL DEFICITS; STEM-CELLS; STROKE; TRANSPLANTATION; INFLAMMATION; MICROGLIA; CHILDREN; MODEL; INFUSION; MOTOR
Issue Date
201203
Publisher
BIOMED CENTRAL LTD
Citation
JOURNAL OF TRANSLATIONAL MEDICINE, v.10
Abstract
Backgrounds: We conducted a pilot study of the infusion of intravenous autologous cord blood (CB) in children with cerebral palsy (CP) to assess the safety and feasibility of the procedure as well as its potential efficacy in countering neurological impairment. Methods: Patients diagnosed with CP were enrolled in this study if their parents had elected to bank their CB at birth. Cryopreserved CB units were thawed and infused intravenously over 10 similar to 20 minutes. We assessed potential efficacy over 6 months by brain magnetic resonance imaging (MRI)-diffusion tensor imaging (DTI), brain perfusion single-photon emission computed tomography (SPECT), and various evaluation tools for motor and cognitive functions. Results: Twenty patients received autologous CB infusion and were evaluated. The types of CP were as follows: 11 quadriplegics, 6 hemiplegics, and 3 diplegics. Infusion was generally well-tolerated, although 5 patients experienced temporary nausea, hemoglobinuria, or urticaria during intravenous infusion. Diverse neurological domains improved in 5 patients (25%) as assessed with developmental evaluation tools as well as by fractional anisotropy values in brain MRI-DTI. The neurologic improvement occurred significantly in patients with diplegia or hemiplegia rather than quadriplegia. Conclusions: Autologous CB infusion is safe and feasible, and has yielded potential benefits in children with CP.
URI
http://hdl.handle.net/YU.REPOSITORY/29612http://dx.doi.org/10.1186/1479-5876-10-58
ISSN
1479-5876
Appears in Collections:
의과대학 > 재활의학교실 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE