Nacre-driven water-soluble factors promote wound healing of the deep burn porcine skin by recovering angiogenesis and fibroblast function

Title
Nacre-driven water-soluble factors promote wound healing of the deep burn porcine skin by recovering angiogenesis and fibroblast function
Author(s)
정대원이경희김현수김진만정연호이태윤임현숙[임현숙]임지혜[임지혜]김태운[김태운]베진성[베진성]우창훈김극준[김극준]
Keywords
OYSTER PINCTADA-FUCATA; OSTEOBLASTS MAINTAINED INVITRO; MATRIX PROTEIN; PEARL OYSTER; COLLAGEN-SYNTHESIS; ORGANIC MATRIX; SHELL; BONE; IMPLANTS; CELLS
Issue Date
201203
Publisher
SPRINGER
Citation
MOLECULAR BIOLOGY REPORTS, v.39, no.3, pp.3211 - 3218
Abstract
To assess the recovery effect of water-soluble components of nacre on wound healing of burns, water-soluble nacre (WSN) was obtained from powdered nacre. Alterations to WSN-mediated wound healing characteristics were examined in porcine skin with deep second-degree burns; porcine skin was used as a proxy for human. When WSN was applied to a burned area, the burn-induced granulation sites were rapidly filled with collagen, and the damaged dermis and epidermis were restored to the appearance of normal skin. WSN enhanced wound healing recovery properties for burn-induced apoptotic and necrotic cellular damage and spurred angiogenesis. Additionally, WSN-treated murine fibroblast NIH3T3 cells showed increased proliferation and collagen synthesis. Collectively, the findings indicate that WSN improves the process of wound healing in burns by expeditiously restoring angiogenesis and fibroblast activity. WSN may be useful as a therapeutic agent, with superior biocompatibility to powdered nacre, and evoking less discomfort when applied to a wounded area.
URI
http://hdl.handle.net/YU.REPOSITORY/29587http://dx.doi.org/10.1007/s11033-011-1088-4
ISSN
0301-4851
Appears in Collections:
의과대학 > 미생물학교실 > Articles
의과대학 > 약리학교실 > Articles
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