Nacre-driven water-soluble factors promote wound healing of the deep burn porcine skin by recovering angiogenesis and fibroblast function
- Nacre-driven water-soluble factors promote wound healing of the deep burn porcine skin by recovering angiogenesis and fibroblast function
- 정대원; 이경희; 김현수; 김진만; 정연호; 이태윤; 임현숙[임현숙]; 임지혜[임지혜]; 김태운[김태운]; 베진성[베진성]; 우창훈; 김극준[김극준]
- OYSTER PINCTADA-FUCATA; OSTEOBLASTS MAINTAINED INVITRO; MATRIX PROTEIN; PEARL OYSTER; COLLAGEN-SYNTHESIS; ORGANIC MATRIX; SHELL; BONE; IMPLANTS; CELLS
- Issue Date
- MOLECULAR BIOLOGY REPORTS, v.39, no.3, pp.3211 - 3218
- To assess the recovery effect of water-soluble components of nacre on wound healing of burns, water-soluble nacre (WSN) was obtained from powdered nacre. Alterations to WSN-mediated wound healing characteristics were examined in porcine skin with deep second-degree burns; porcine skin was used as a proxy for human. When WSN was applied to a burned area, the burn-induced granulation sites were rapidly filled with collagen, and the damaged dermis and epidermis were restored to the appearance of normal skin. WSN enhanced wound healing recovery properties for burn-induced apoptotic and necrotic cellular damage and spurred angiogenesis. Additionally, WSN-treated murine fibroblast NIH3T3 cells showed increased proliferation and collagen synthesis. Collectively, the findings indicate that WSN improves the process of wound healing in burns by expeditiously restoring angiogenesis and fibroblast activity. WSN may be useful as a therapeutic agent, with superior biocompatibility to powdered nacre, and evoking less discomfort when applied to a wounded area.
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