Citreorosein, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, attenuates cyclooxygenase-2-dependent prostaglandin D-2 generation by blocking Akt and JNK pathways in mouse bone marrow-derived mast cells

Title
Citreorosein, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, attenuates cyclooxygenase-2-dependent prostaglandin D-2 generation by blocking Akt and JNK pathways in mouse bone marrow-derived mast cells
Author(s)
장현욱유예[유예]서석종이선[이선]황승락이응[이응]황보경[황보경]박순진[박순진]Makoto Murakami[Makoto Murakami]이승호장영동손종근김철호[김철호]
Keywords
NF-KAPPA-B; C-KIT LIGAND; TRANSCRIPTION FACTOR; IN-VIVO; CHEMOTACTIC ACTIVITY; PHOSPHOLIPASE A(2); SIGNALING PATHWAY; CROSS-LINKING; LAVAGE FLUID; ACTIVATION
Issue Date
201203
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
FOOD AND CHEMICAL TOXICOLOGY, v.50, no.3-4, pp.913 - 919
Abstract
In this study, we examined the effects of citreorosein (CIT), an anthraquinone component of Polygonui cuspidati radix (P. cuspidati, Polygonaceae), on cyclooxygenase (COX)-2 dependent prostaglandin (PG)D-2 generation in mast cells, central effector cells of allergy and other inflammatory diseases. CIT strongly inhibited COX-2-dependent PGD(2) generation in a concentration-dependent manner in mouse bone marrow-derived mast cells (BMMCs) stimulated with stem cell factor (SCF)/IL-10/LPS. In an effort to identify the mechanisms underlying the inhibition of COX-2-dependent PGD(2) generation by CIT, we examined the effects of this compound on MAP kinases, Akt and NF-kappa B signaling pathways, which are essential for COX-2 induction. CIT inhibited nuclear translocation of the nuclear factor (NF)-kappa B p65 sub-unit and its cognate DNA-binding activity, which correlated with its inhibitory effects on the phosphorylation of Akt and IKK and subsequent phosphorylation and degradation of I kappa B. Furthermore, CIT significantly attenuated the DNA binding of activator protein (AP)-1 that regulates COX-2 expression through the reduction of the phosphorylation of c-Jun. Moreover, inhibition of PGD(2) generation by CIT was accompanied by a decrease in phosphorylation of cytosolic phospholipase A(2)alpha. Taken together, the present study suggests that CIT represents a potential therapeutic approach for the treatment of inflammatory diseases. 0 2011 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/29572http://dx.doi.org/10.1016/j.fct.2011.11.046
ISSN
0278-6915
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약학대학 > 약학부 > Articles
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