4-O-Methylhonokiol Prevents Memory Impairment in the Tg2576 Transgenic Mice Model of Alzheimer's Disease Via Regulation of beta-Secretase Activity

Title
4-O-Methylhonokiol Prevents Memory Impairment in the Tg2576 Transgenic Mice Model of Alzheimer's Disease Via Regulation of beta-Secretase Activity
Author(s)
최동영이영중[이영중]이용경[이용경]이윷모[이윷모]한상배[한상배]김영희[김영희]김기호[김기호]남상윤[남상윤]이범준[이범준]강종구[강종구]윤영원[윤영원]오기완[오기완]홍진태[홍진태]
Keywords
AMYLOID PRECURSOR PROTEIN; NF-KAPPA-B; OXIDATIVE STRESS; MOUSE MODEL; A-BETA; MAGNOLIA-OFFICINALIS; INTERFERON-GAMMA; INFLAMMATORY RESPONSE; COGNITIVE IMPAIRMENT; BACE1 EXPRESSION
Issue Date
201203
Publisher
IOS PRESS
Citation
JOURNAL OF ALZHEIMERS DISEASE, v.29, no.3, pp.677 - 690
Abstract
Alzheimer's disease (AD), the most common form of dementia, is characterized by memory deficits and deposition of amyloid-beta (A beta) in the brain. It has been known that neuroinflammation and oxidative stress are critical factors in the development of AD. 4-O-methylhonokiol, an extract from Magnolia officinalis, is known to have anti-inflammatory and anti-oxidative effects. Thus, we investigated the properties of 4-O-methylhonokiol against progression and development of AD in Tg2576 mice. Tg2576 mice models show memory impairment and AD-like pathological features including A beta deposition. Oral administration of 4-O-methylhonokiol through drinking water (1 mg/kg in 0.0002% Tween 80) for 12 weeks not only prevented memory impairment but also inhibited A beta deposition. In addition, 4-O-methylhonokiol decreased beta-secretase activity, oxidative lipid and protein damage levels, activation of astrocytes and microglia cells, and generation of IL-1 beta and TNF-alpha with increase of glutathione level in the brain. Our results showed that 4-O-methylhonokiol effectively prevented memory impairment by down-regulating beta-secretase activity through inhibition of oxidative stress and neuroinflammatory responses in Tg2576 transgenic mice.
URI
http://hdl.handle.net/YU.REPOSITORY/29569http://dx.doi.org/10.3233/JAD-2012-111835
ISSN
1387-2877
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약학대학 > 약학부 > Articles
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