Development of novel ibuprofen-loaded solid dispersion with enhanced bioavailability using cycloamylose

Title
Development of novel ibuprofen-loaded solid dispersion with enhanced bioavailability using cycloamylose
Author(s)
용철순백형희[백형희]김대환[김대환]권소영[권소영]노신정[노신정]김동욱[김동욱]최한곤[최한곤]김용로[김용로]
Keywords
BETA-CYCLODEXTRIN; GELATIN MICROCAPSULE; COMPLEX-FORMATION; AQUEOUS-SOLUTION; DISSOLUTION; SOLUBILITY; INCLUSION; POLOXAMER-188; FLURBIPROFEN
Issue Date
201203
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.35, no.4, pp.683 - 689
Abstract
To develop a novel ibuprofen-loaded solid dispersion with enhanced bioavailability using cycloamylose, it was prepared using spray-drying techniques with cycloamylose at a weight ratio of 1:1. The effect of cycloamylose on aqueous solubility of ibuprofen was investigated. The physicochemical properties of solid dispersions were investigated using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction. The dissolution and bioavailability in rats were evaluated compared with ibuprofen powder. This ibuprofen-loaded solid dispersion improved about 14-fold drug solubility. Ibuprofen was present in an unchanged crystalline state, and cycloamylose played the simple role of a solubilizing agent in this solid dispersion. Moreover, the dispersion gave 2-fold higher AUC (area under the drug concentration-time curve) value compared with a ibuprofen powder, indicating that it improved the oral bioavailability of ibuprofen in rats. Thus, the solid dispersion may be useful to deliver ibuprofen with enhanced bioavailability without crystalline change.
URI
http://hdl.handle.net/YU.REPOSITORY/29527http://dx.doi.org/10.1007/s12272-012-0412-4
ISSN
0253-6269
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약학대학 > 약학부 > Articles
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