Correlations Between the Level of High-Sensitivity C-Reactive Protein and Cardiovascular Risk Factors in Korean Adults with Cardiovascular Disease or Diabetes Mellitus: The CALLISTO Study

Title
Correlations Between the Level of High-Sensitivity C-Reactive Protein and Cardiovascular Risk Factors in Korean Adults with Cardiovascular Disease or Diabetes Mellitus: The CALLISTO Study
Author(s)
박종선서석민[서석민]백상홍[백상홍]전희경[전희경]강석민[강석민]김동수[김동수]김우식[김우식]김형섭[김형섭]라승운[라승운]성인환[성인환]안영근[안영근]윤정한[윤정한]차태준[차태준]
Keywords
CORONARY-HEART-DISEASE; APPARENTLY HEALTHY-MEN; HDL-CHOLESTEROL; LDL CHOLESTEROL; ARTERY-DISEASE; STATIN THERAPY; FUTURE RISK; INFLAMMATION; PREDICTION; EVENTS
Issue Date
201307
Publisher
JAPAN ATHEROSCLEROSIS SOC
Citation
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, v.20, no.7, pp.616 - 622
Abstract
Aim: We assessed the relationship between the level of high-sensitivity C-reactive protein (hsCRP) and cardiovascular risk factors in Korean adults. Methods: We reviewed 1,561 patients with cardiovascular disease or diabetes mellitus with hsCRP levels measured within the past year. Four cardiovascular risk groups were determined: low (<10%, 0-1 risk), moderate (<10%, >2 risk), high (10-20%) and very high (>20%) risk, according to the number of risk factors and the Framingham/NCEP ATP. risk score. The correlations between the hsCRP level and cardiovascular risk factors (age, smoking, hypertension, lipid profiles and familial history of premature coronary heart disease) were investigated. Results: The mean and median hsCRP (mg/L) levels were 1.32 +/- 9.69 and 0.29 (range: 0.01-7.48), respectively. Men had a higher median level of hsCRP than women (p<0.001). The levels of hs CRP significantly increased from the low to the very high risk group (0.15, 0.23, 0.27 and 0.47, respectively) and were significantly correlated with age, the level of glycosylated hemoglobin, body mass index (BMI), the level of high-density lipoprotein cholesterol (HDL-C), the low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio, the LDL-C/total cholesterol (TC) ratio, the HDL-C/TC ratio, the HDL-C/triglyceride (TG) ratio and the TC/TG ratio. Neither smoking, the LDL-C level nor the TG level affected the hsCRP level. In a multivariate regression analysis, age, the HDL-C level, the LDL-C/TC ratio and BMI were found to be independently correlated with the hsCRP level. Conclusions: There is a significant relationship between the degree of cardiovascular risk and the hsCRP level in Korean adults with cardiovascular disease or diabetes mellitus. Assessing the hsCRP levels may thus provide additive value in predicting cardiovascular risks.
URI
http://hdl.handle.net/YU.REPOSITORY/29321
ISSN
1340-3478
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의과대학 > 내과학교실 > Articles
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