Modulated Crosslinking of Macroporous Polymeric Cryogel Affects In Vitro Cell Adhesion and Growth

Title
Modulated Crosslinking of Macroporous Polymeric Cryogel Affects In Vitro Cell Adhesion and Growth
Author(s)
딥티싱Anuj Tripathi[Anuj Tripathi]Tanushree Vishnoi[Tanushree Vishnoi]Ashok Kumar[Ashok Kumar]
Keywords
AGAROSE-GELATIN CRYOGELS; EMBRYOID BODY FORMATION; STEM-CELLS; COLLAGEN-FIBERS; STROMAL CELLS; ALGINATE; SCAFFOLDS; BIOMATERIALS; RGD; DIFFERENTIATION
Issue Date
201307
Publisher
WILEY-V C H VERLAG GMBH
Citation
MACROMOLECULAR BIOSCIENCE, v.13, no.7, pp.838 - 850
Abstract
Cell to matrix interactions affect in vitro cell adherence and proliferation and further decide the fate of tissue development for biomedical applications. This study demonstrates the role of crosslinking in altering the surface properties of 3D porous cryogel matrices. Glutaraldehyde and 1-ethyl-3(3-dimethylaminopropyl)-carbodiimide crosslinkers are used separately for the crosslinking of alginate and gelatin (i.e., AG(G) and AG(EN)), respectively. The difference in crosslinking affects the physiochemical properties of these matrices leading to variable cell behavior as demonstrated using four different cell types, which show homogeneous cell growth in AG(G) and spheroid cell growth in AG(EN). The present study shows successful use of controlled crosslinking in directing the cell growth for tissue engineering.
URI
http://hdl.handle.net/YU.REPOSITORY/29314http://dx.doi.org/10.1002/mabi.201200398
ISSN
1616-5187
Appears in Collections:
중앙도서관 > rims journal
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