Porcine insulin-like growth factor 1 (IGF1) gene polymorphisms are associated with body size variation

Title
Porcine insulin-like growth factor 1 (IGF1) gene polymorphisms are associated with body size variation
Author(s)
김종주Pengxia Niu[Pengxia Niu]김상욱[김상욱]최봉환[최봉환]김태헌[김태헌]김관석[김관석]
Keywords
MEAT QUALITY TRAITS; I CONCENTRATION; ADULT HEIGHT; POPULATION; CARCASS; LOCI
Issue Date
201308
Publisher
SPRINGER
Citation
GENES & GENOMICS, v.35, no.4, pp.523 - 528
Abstract
Previous studies have confirmed that insulin growth factor-1 (IGF1) plays important roles in growth and body size in humans and animals. However, whether single nucleotide polymorphisms (SNPs) within the IGF1 gene affects body size and growth in pigs has been unclear. We identified IGF1 SNPs among 5 pig breeds (Berkshire, Duroc, Landrace, Yorkshire and Korea Native Pig) and found that the G allele of SNP (c.G189A) was associated with higher body weight and was more predominant in western pig breeds, while the Korean Native Pig is the breed with the highest frequency of the A allele. Four haplotypes (-GA-, -GG-, -AG-, and -AA-) were constructed using the 2 identified SNPs. The GA haplotype was most frequently observed, except in the Berkshire breed. In addition, these SNPs and haplotypes were significantly associated with body size (final weight), average daily gain, and backfat thickness (P < 0.05) in 2 intercrossed F-2 pig populations (KNP x YS F-2 and KNP x LR F-2). Furthermore, the major GA haplotype had a significant additive effect on body size and average daily gain. In conclusion, specific SNPs within the porcine IGF1 gene may contribute to the smaller body size and lower growth rate of Korea Native Pigs.
URI
http://hdl.handle.net/YU.REPOSITORY/29259http://dx.doi.org/10.1007/s13258-013-0098-0
ISSN
1976-9571
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