Curcumin inhibits oxLDL-induced CD36 expression and foam cell formation through the inhibition of p38 MAPK phosphorylation

Title
Curcumin inhibits oxLDL-induced CD36 expression and foam cell formation through the inhibition of p38 MAPK phosphorylation
Author(s)
조경현민경진[민경진]음희정[음희정]권택규[권택규]
Keywords
LOW-DENSITY-LIPOPROTEIN; SCAVENGER RECEPTOR CD36; PPAR-GAMMA; OXIDIZED LDL; SR-BI; MURINE MACROPHAGES; ANIONIC PHOSPHOLIPIDS; COX-2 EXPRESSION; GENE-EXPRESSION; A-I
Issue Date
201308
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
FOOD AND CHEMICAL TOXICOLOGY, v.58, pp.77 - 85
Abstract
The uptake of oxidized low density lipoprotein (oxLDL) via scavenger receptors transforms macrophages into foam cells, which are a hallmark of atherosclerosis. OxLDL markedly increases the expression of the CD36 scavenger receptor. Here, we investigated whether curcumin modulate CD36 expression in oxLDL-treated RAW 264.7 murine macrophages. Our results showed that curcumin dramatically inhibits CD36 expression and foam cell formation. Furthermore, oxLDL-induced expression and activity of peroxisome proliferator-activated receptor-gamma (PPAR-gamma), which is involved in CD36 expression, is also blocked in curcumin-treated cells. OxLDL activates the mitogen-activated protein kinase (MAPK) signaling transduction pathway, and p38 MAPK is associated with oxLDL-induced CD36 and PPAR-gamma expression. Overexpression of dominant negative p38 MAPK blocks oxLDL-induced CD36 and PPAR-gamma expression. Furthermore, curcumin markedly inhibits p38 MAPK phosphorylation. Taken together, our results suggest that curcumin modulates oxLDL-induced CD36 expression and foam cell formation via the inhibition of p38 MAPK phosphorylation in RAW 264.7 murine macrophages. (C) 2013 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/29239http://dx.doi.org/10.1016/j.fct.2013.04.008
ISSN
0278-6915
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생명공학부 > 생명공학부 > Articles
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