Efficient one-step synthesis of pyrrolo[3,4-c]quinoline-1,3-dione derivatives by organocatalytic cascade reactions of isatins and beta-ketoamides

Title
Efficient one-step synthesis of pyrrolo[3,4-c]quinoline-1,3-dione derivatives by organocatalytic cascade reactions of isatins and beta-ketoamides
Author(s)
이용록하립개
Keywords
POTENT CASPASE-3 INHIBITORS; CATALYZED INTRAMOLECULAR CYCLIZATION; SMALL-MOLECULE INHIBITORS; (+/-)-DAURICHROMENIC ACID; CHEMICAL-TRANSFORMATIONS; ACRIDINE-DERIVATIVES; ASYMMETRIC-SYNTHESIS; APOPTOSIS; LIBRARY; 3-ALKYLIDENEOXINDOLES
Issue Date
201308
Publisher
ROYAL SOC CHEMISTRY
Citation
ORGANIC & BIOMOLECULAR CHEMISTRY, v.11, no.32, pp.5254 - 5263
Abstract
We describe an efficient one-step synthesis of pyrrolo[3,4-c]quinolinedione derivatives using ethylenediamine diacetate (EDDA)-catalyzed cascade reactions of isatins and beta-ketoamides. It is the first direct conversion of isatins to pyrrolo[3,4-c]quinolinedione derivatives via C-N bond cleavage and isatin ring expansion. Furthermore, this reaction provides a one-step synthetic route for the production of biologically interesting complex molecules that are generally prepared using multi-step reactions.
URI
http://hdl.handle.net/YU.REPOSITORY/29217http://dx.doi.org/10.1039/c3ob40791h
ISSN
1477-0520
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공과대학 > 화학공학부 > Articles
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