The Methionine Sulfoxide Reduction System: Selenium Utilization and Methionine Sulfoxide Reductase Enzymes and Their Functions

Title
The Methionine Sulfoxide Reduction System: Selenium Utilization and Methionine Sulfoxide Reductase Enzymes and Their Functions
Author(s)
김화영
Keywords
PROTEIN-BOUND METHIONINE; R-SULFOXIDE; ESCHERICHIA-COLI; OXIDATIVE STRESS; SACCHAROMYCES-CEREVISIAE; ENDOPLASMIC-RETICULUM; CATALYTIC MECHANISM; HYDROGEN-SULFIDE; LIFE-SPAN; SELENOCYSTEINE INSERTION
Issue Date
201308
Publisher
MARY ANN LIEBERT, INC
Citation
ANTIOXIDANTS & REDOX SIGNALING, v.19, no.9, pp.958 - 969
Abstract
Significance: Selenium is utilized in the methionine sulfoxide reduction system that occurs in most organisms. Methionine sulfoxide reductases (Msrs), MsrA and MsrB, are the enzymes responsible for this system. Msrs repair oxidatively damaged proteins, protect against oxidative stress, and regulate protein function, and have also been implicated in the aging process. Selenoprotein forms of Msrs containing selenocysteine (Sec) at the catalytic site are found in bacteria, algae, and animals. Recent Advances: A selenoprotein MsrB1 knockout mouse has been developed. Significant progress in the biochemistry of Msrs has been made, which includes findings of a novel reducing system for Msrs and of an interesting reason for the use of Sec in the Msr system. The effects of mammalian MsrBs, including selenoprotein MsrB1 on fruit fly aging, have been investigated. Furthermore, it is evident that Msrs are involved in methionine metabolism and regulation of the trans-sulfuration pathway. Critical Issues: This article presents recent progress in the Msr field while focusing on the physiological roles of mammalian Msrs, functions of selenoprotein forms of Msrs, and their biochemistry. Future Directions: A deeper understanding of the roles of Msrs in redox signaling, the aging process, and metabolism will be achieved. The identity of selenoproteome of Msrs will be sought along with characterization of the identified selenoprotein forms. Exploring new cellular targets and new functions of Msrs is also warranted.
URI
http://hdl.handle.net/YU.REPOSITORY/29214http://dx.doi.org/10.1089/ars.2012.5081
ISSN
1523-0864
Appears in Collections:
의과대학 > 생화학.분자생물학교실 > Articles
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