Does gender influence the impact of impaired renal function on prognosis after ST-segment elevated myocardial infarction?

Title
Does gender influence the impact of impaired renal function on prognosis after ST-segment elevated myocardial infarction?
Author(s)
김영조김수완[김수완]최준석[최준석]김민지[김민지]강영운[강영운]김창성[김창성]배은휘[배은휘]마성권[마성권]안영근[안영근]정명호[정명호]
Keywords
PERCUTANEOUS CORONARY INTERVENTION; GLOMERULAR-FILTRATION-RATE; CARDIOVASCULAR OUTCOMES; SEX-DIFFERENCES; WOMEN; MEN; MORTALITY; INSUFFICIENCY; EQUATION; REGISTRY
Issue Date
201309
Publisher
VIA MEDICA
Citation
CARDIOLOGY JOURNAL, v.20, no.5, pp.526 - 532
Abstract
Background: A limited number of studies have investigated the impact of gender on renal function and clinical outcomes after ST-segment elevated myocardial infarction (STEMI), and these studies have provided discrepant results. Methods and Results: This study was based on a retrospective cohort, the Korean Acute Myocardial Infarction Registry (KAMIR). Patients (n = 7,679) with a discharge diagnosis of STEMI were analyzed to investigate association of gender with renal function and clinical outcomes. Compared to men, women were older and exhibited more comorbidity, including impaired renal function. Women showed higher mortality compared to men (1-month mortality, 5.6% in men vs. 12.6% in women, p < 0.001; 1-year mortality, 6.8% in men vs. 14.4% in women, p < 0.001). The risk of death proportionally increased as estimated glomerular filtration rate (eGFR) decreased in both genders. After adjusting for potential confounders, hazard ratios for women did not significantly differ from those for men at each eGFR level. The interaction test showed no significant interaction between gender and eGFR in 1-month mortality and 1-year mortality. Conclusions: Impaired renal function was an independent prognostic factor after STEMI in both genders, and the impact of impaired renal function on prognosis after STEMI did not significantly differ between genders.
URI
http://hdl.handle.net/YU.REPOSITORY/29021http://dx.doi.org/10.5603/CJ.2013.0138
ISSN
1897-5593
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의과대학 > 내과학교실 > Articles
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