Influence of Renal Dysfunction on Clinical Outcomes in Patients With Congestive Heart Failure Complicating Acute Myocardial Infarction

Title
Influence of Renal Dysfunction on Clinical Outcomes in Patients With Congestive Heart Failure Complicating Acute Myocardial Infarction
Author(s)
김영조김창성[김창성]김민지[김민지]김수완[김수완]배은희[배은희]마성관[마성관]안영균[안영균]정명호[정명호]조명찬[조명찬]김종진[김종진]
Keywords
CHRONIC KIDNEY-DISEASE; ACUTE CORONARY SYNDROMES; CARDIOVASCULAR OUTCOMES; RISK STRATIFICATION; NATIONAL-REGISTRY; INFLAMMATION; PREDICTORS; MANAGEMENT; MORTALITY; SURVIVORS
Issue Date
201309
Publisher
INT HEART JOURNAL ASSOC
Citation
INTERNATIONAL HEART JOURNAL, v.54, no.5, pp.304 - 310
Abstract
The clinical course and medical treatment of patients with congestive heart failure (CHF) complicating acute myocardial infarction (ANT) are not well established, especially in patients with concomitant renal dysfunction. We performed a retrospective analysis of the prospective Korean Acute Myocardial Infarction Registry to assess the medical treatments and clinical outcomes of patients with CHF (Killip classes II or III) complicated by ANT, in the presence or absence of renal dysfunction. Of 13,498 patients with AMI, 2769 (20.5%) had CHIP on admission. Compared to CHF patients with preserved renal function, in-hospital mortality and major adverse cardiac events were increased both at 1 month and at 1 year after discharge in patients with renal dysfunction (1154; 41.7%). Postdischarge use of aspirin, beta-blockers, calcium channel blockers, angiotensin-converting enzyme inhibitors, or angiotensin 11 receptor blockers and statins significantly reduced the 1-year mortality rate for CHIP patients with renal dysfunction; such reduction was not observed for those without renal dysfunction, except in the case of aspirin. Patients with CHIP complicating AMI, which is accompanied by renal dysfunction, are at higher risk for adverse cardiovascular outcomes than patients without renal dysfunction. However, they receive fewer medications proven to reduce mortality rates.
URI
http://hdl.handle.net/YU.REPOSITORY/29002
ISSN
1349-2365
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의과대학 > 내과학교실 > Articles
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