The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis

Title
The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis
Author(s)
백석환김상두[김상두]권순일[권순일]이성균[이성균]국민수[국민수]이하영[이하영]송기덕[송기덕]이학교[이학교]박찬배[박찬배]배외식[배외식]
Keywords
INFLAMMATORY-BOWEL-DISEASE; VAL-D-MET; CROHNS-DISEASE; PHOSPHOINOSITIDE HYDROLYSIS; INTESTINAL INFLAMMATION; SUPEROXIDE GENERATION; TARGETED DISRUPTION; TGF-BETA; RECEPTOR; ACTIVATION
Issue Date
201309
Publisher
NATURE PUBLISHING GROUP
Citation
EXPERIMENTAL AND MOLECULAR MEDICINE, v.45
Abstract
In this study, we examined the therapeutic effects of an immune-stimulating peptide, WKYMVm, in ulcerative colitis. The administration of WKYMVm to dextran sodium sulfate (DSS)-treated mice reversed decreases in body weight, bleeding score and stool score in addition to reversing DSS-induced mucosa destruction and shortened colon. The WKYMVm-induced therapeutic effect against ulcerative colitis was strongly inhibited by a formyl peptide receptor (FPR) 2 antagonist, WRWWWW, indicating the crucial role of FPR2 in this effect. Mechanistically, WKYMVm effectively decreases intestinal permeability by stimulating colon epithelial cell proliferation. WKYMVm also strongly decreases interleukin-23 and transforming growth factor-beta production in the colon of DSS-treated mice. We suggest that the potent immune-modulating peptide WKYMVm and its receptor FPR2 may be useful in the development of efficient therapeutic agents against chronic intestinal inflammatory diseases.
URI
http://hdl.handle.net/YU.REPOSITORY/28990http://dx.doi.org/10.1038/emm.2013.77
ISSN
1226-3613
Appears in Collections:
의과대학 > 생화학.분자생물학교실 > Articles
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