Efficient One-Pot Synthesis of Spirooxindole Derivatives Bearing Hexahydroquinolines Using Multicomponent Reactions Catalyzed by Ethylenediamine Diacetate

Title
Efficient One-Pot Synthesis of Spirooxindole Derivatives Bearing Hexahydroquinolines Using Multicomponent Reactions Catalyzed by Ethylenediamine Diacetate
Author(s)
이용록강소랑
Keywords
MAMMALIAN-CELL CYCLE; PYRANOCHALCONE NATURAL-PRODUCTS; PUMMERER REACTION CHEMISTRY; BRADYKININ B-2 RECEPTOR; SOLVENT-FREE CONDITIONS; CONCISE TOTAL-SYNTHESIS; POLYHYDROQUINOLINE DERIVATIVES; ASPERGILLUS-FUMIGATUS; HANTZSCH REACTION; ASYMMETRIC-SYNTHESIS
Issue Date
201309
Publisher
GEORG THIEME VERLAG KG
Citation
SYNTHESIS-STUTTGART, v.45, no.18, pp.2593 - 2599
Abstract
A simple and efficient one-pot synthesis of biologically interesting spirooxindole derivatives bearing hexahydroquinoline skeleton was accomplished by EDDA-catalyzed, three-component reactions between isatins, malononitrile, and enaminones in good yields. The value of this methodology lies in its inexpensive and nontoxic organocatalyst, mild reaction conditions, and ease of handling.
URI
http://hdl.handle.net/YU.REPOSITORY/28989http://dx.doi.org/10.1055/s-0033-1338506
ISSN
0039-7881
Appears in Collections:
공과대학 > 화학공학부 > Articles
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