Estrogen Rather Than Progesterone Cause Constipation in Both Female and Male Mice

Title
Estrogen Rather Than Progesterone Cause Constipation in Both Female and Male Mice
Author(s)
김종연Ji-Eun Oh[Ji-Eun Oh]김용운박소영
Keywords
SLOW-TRANSIT CONSTIPATION; IRRITABLE-BOWEL-SYNDROME; GASTROINTESTINAL TRANSIT; MENSTRUAL-CYCLE; NANC NERVES; PREGNANCY; MOTILITY; GENDER; DISORDERS; COLON
Issue Date
201310
Publisher
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
Citation
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.17, no.5, pp.423 - 426
Abstract
Females are more often affected by constipation than males, especially during pregnancy, which is related to the menstrual cycle. Although still controversial, alterations of progesterone and estrogen may be responsible. Therefore, this study was conducted in order to determine whether the female sex steroid hormone itself is responsible for development of constipation in both female and male mice. Administration of estrogen resulted in a decrease in weight of accumulated feces on days 2, 3, 4, and 5 in male mice and on day 5 in female mice, compared with the control group, but progesterone administration did not. Administration of estrogen resulted in a decrease in gastrointestinal movement, compared to normal; however, no significant change was observed by administration of progesterone. In conclusion, estrogen, rather than progesterone, may be a detrimental factor of constipation via decreased bowel movement in mice.
URI
http://hdl.handle.net/YU.REPOSITORY/28853http://dx.doi.org/10.4196/kjpp.2013.17.5.423
ISSN
1226-4512
Appears in Collections:
의과대학 > 생리학교실 > Articles
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