Comparison of osteogenesis in poly(L-lactic acid)-coated and non-coated porous hydroxyapatite scaffolds
- Comparison of osteogenesis in poly(L-lactic acid)-coated and non-coated porous hydroxyapatite scaffolds
- 김용하; 김일국; 김태곤; 이준호; 최준혁; 김윤정[김윤정]; 최석영[최석영]
- AMORPHOUS CALCIUM-PHOSPHATE; COMPOSITE SCAFFOLDS; BONE; CERAMICS; PHASE; FOAMS
- Issue Date
- JOURNAL OF POROUS MATERIALS, v.20, no.5, pp.1031 - 1039
- To improve the biocompatibility and mechanical strength of porous hydroxyapatite (HA) scaffolds that have high osteoconduction, we coated them with 1, 5, or 10 wt% poly(L-lactic acid) (PLLA). In the 5 and 10 wt% PLLA-coated groups, osteoblast proliferation rates were higher than those in non-coated and 1 wt% PLLA-coated groups. The alkaline phosphatase (ALP) activity was highest in the 5 wt% PLLA-coated group. In addition, the porosity was highest in the non-coated HA group (82 %), whereas it was 72, and 41 % in the 5, and 10 wt% PLLA-coated groups, respectively. Scaffold strength increased in proportion to the concentration of PLLA coating. Overall, the 5 wt% PLLA scaffold had best characteristics when considering osteoblast proliferation, ALP activity, porosity, and compressive strength. We next tested this scaffold in an in vivo alveolar defect rabbit model. Multi-detector row computed tomography showed that non-coated and 5 wt% PLLA-coated HA groups had a similar high density. Adequate osteogenesis was observed by histological analysis in the non-coated HA and 5 wt% PLLA-coated HA groups. In addition, sufficient mineralization was observed in the coated scaffolds by X-ray fluorescence spectroscopy without significant adverse effects. Therefore, based on our findings, a PLLA-coated porous HA scaffold may be a suitable bone substitute for the correction of bone defects.
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