Fibronectin expression in carcinoma cells correlates with tumor aggressiveness and poor clinical outcome in patients with invasive breast cancer

Title
Fibronectin expression in carcinoma cells correlates with tumor aggressiveness and poor clinical outcome in patients with invasive breast cancer
Author(s)
배영경김애리[김애리]김민경최정은강수환이수정
Keywords
EPITHELIAL-MESENCHYMAL TRANSITION; IMMUNOHISTOCHEMICAL EXPRESSION; TISSUE MICROARRAY; LUNG-CANCER; GROWTH; TENASCIN; ACTIVATION; EXPERIENCE; PROGNOSIS; LAMININ
Issue Date
201310
Publisher
W B SAUNDERS CO-ELSEVIER INC
Citation
HUMAN PATHOLOGY, v.44, no.10, pp.2028 - 2037
Abstract
Fibronectin (FN), a large heterodimeric glycoprotein, can be found in soluble form in plasma or in insoluble form as an extracellular matrix protein. Cellular FN is produced by various types of benign and malignant epithelial and mesenchymal cells and is widely distributed in malignant tumors. We evaluated FN expression in cancer cells (epithelial FN; E-FN) and intratumor stroma (stromal FN, S-FN) of 1596 invasive breast cancer samples using immunohistochemistry on tissue microarrays. Correlations of FN expression with clinicopathologic factors and patient survival were investigated. Among 1512 informative cases, E-FN expression was observed in 355 (23.5%) cases, and S-FN expression showed no/weak staining in 362 (23.9%), moderate staining in 744 (49.2%), and strong staining in 406 (26.9%) cases. E-FN expression was correlated with advanced pT (P < .001) and pN (P < .001), histologic type (P = .006), high histologic grade (P < .001), lymphovascular invasion (P < .001), hormone receptor negativity (P < .001), and human epidermal growth factor receptor-2 (HER2) positivity (P < .001). Strong S-FN expression showed an association with advanced pN (P = .002), histologic type (P < .001), high histologic grade (P < .001), lymphovascular invasion (P < .001), and HER2 positivity (P < .001). Patients with E-FN expression showed worse overall survival (P < .001) and disease-free survival (P < .001) than did those with negative expression of FN. E-FN expression was an independent prognostic factor, especially in the hormone receptor positive group. Expression of S-FN, did not have a significant effect on patient survival. In conclusion, E-FN expression could be a promising prognostic marker in patients with invasive breast cancer. (C) 2013 Elsevier Inc. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/28844http://dx.doi.org/10.1016/j.humpath.2013.03.006
ISSN
0046-8177
Appears in Collections:
의과대학 > 병리학교실 > Articles
의과대학 > 내과학교실 > Articles
의과대학 > 성형외과학교실 > Articles
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