Epithelial-mesenchymal transition phenotype is associated with patient survival in small intestinal adenocarcinoma

Title
Epithelial-mesenchymal transition phenotype is associated with patient survival in small intestinal adenocarcinoma
Author(s)
배영경김애리[김애리]구미진김정연[김정연]장규윤[장규윤]배한익[배한익]이희진[이희진]홍승모[홍승모]
Keywords
CELL LUNG-CANCER; E-CADHERIN; IMMUNOHISTOCHEMICAL EXPRESSION; CLINICAL-SIGNIFICANCE; GASTRIC-CANCER; BREAST-CANCER; VIMENTIN EXPRESSION; PROGNOSTIC-FACTOR; CARCINOMA; FIBRONECTIN
Issue Date
201310
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
PATHOLOGY, v.45, no.6, pp.567 - 573
Abstract
Aims:We investigated the clinical significance of epithelial-mesenchymal transition (EMT) phenotype in 184 small intestinal adenocarcinomas (SIACs) based on the expression pattern of EMT-related proteins in cancer cells.Methods:Immunohistochemistry for epithelial (E-cadherin) and mesenchymal (vimentin and fibronectin) markers were performed and cases of SIAC were classified into four subtypes of EMT: complete type (E-cadherin-, vimentin+ and/or fibronectin+), wild type (E-cadherin+, vimentin-, fibronectin-), incomplete 1 type (hybrid type; E-cadherin+, vimentin+ and/or fibronectin+), and incomplete 2 type (null type; E-cadherin-, vimentin-, fibronectin-).Results:We identified 19 (10.3%) cases of complete EMT type, 86 (46.7%) cases of wild type and 79 (43%) cases of incomplete EMT type [hybrid type, 22 (12%) cases; null type, 57 (31%) cases]. Complete EMT phenotype showed a significant association with undifferentiated histology (p<0.001). Overall survival of SIAC patients with complete EMT phenotype was significantly shorter than those of patients with incomplete (p=0.001) and wild (p<0.001) types. In multivariate analysis, complete EMT phenotype was an independent prognostic factor in SIAC patients (hazard ratio 2.3; 95% confidence interval 1.15-4.6; p=0.019).Conclusion:Complete EMT phenotype stratifies a specific group representing a poor clinical outcome in patients with SIAC.
URI
http://hdl.handle.net/YU.REPOSITORY/28832http://dx.doi.org/10.1097/PAT.0b013e3283650bab
ISSN
0031-3025
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의과대학 > 병리학교실 > Articles
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