Flurbiprofen-loaded nanoparticles prepared with polyvinylpyrrolidone using Shirasu porous glass membranes and a spray-drying technique: nano-sized formation and improved bioavailability

Title
Flurbiprofen-loaded nanoparticles prepared with polyvinylpyrrolidone using Shirasu porous glass membranes and a spray-drying technique: nano-sized formation and improved bioavailability
Author(s)
용철순오동훈Din,Fahkar Ud[Din,Fahkar Ud]김동욱[김동욱]김종오최한곤[최한곤]
Keywords
SOLID-DISPERSION METHOD; ENHANCED BIOAVAILABILITY; GELATIN MICROCAPSULE; RELEASE
Issue Date
201310
Publisher
INFORMA HEALTHCARE
Citation
JOURNAL OF MICROENCAPSULATION, v.30, no.7, pp.674 - 680
Abstract
A unique flurbiprofen-loaded nanoemulsion was listed earlier using a Shirasu porous glass (SPG) membrane emulsification technique, which gave constant emulsion droplets with a thin size distribution. In this study, a flurbiprofen-loaded nanoemulsion was developed further into a solid form using polyvinylpyrrolidone (PVP) as a carrier by a spray-drying technique. The flurbiprofen-loaded nanoparticles with a weight ratio of flurbiprofen/PVP/surfactant mixture of 1/8/2 were connected with about 130 000-fold enhanced drug solubility and had a mean size of about 70 nm. In these nanoparticles, flurbiprofen was found in an altered amorphous state. Additionally, the nanoparticles gave significantly shorter T-max, and greater AUC and C-max compared to the commercially available product. Specially, the AUC of the drug from the nanoparticles was about 10-fold greater compared to the commercially available product. Therefore, these flurbiprofen-loaded nanoparticles can be convenient for distributing a poorly water-soluble flurbiprofen with improved bioavailability using uniform nano-sized particles.
URI
http://hdl.handle.net/YU.REPOSITORY/28829http://dx.doi.org/10.3109/02652048.2013.774447
ISSN
0265-2048
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약학대학 > 약학부 > Articles
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